Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/bdra.23137 http://scihub22266oqcxt.onion/10.1002/bdra.23137 C5893146!5893146!23716465     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Birth+Defects+Res+A+Clin+Mol+Teratol 2013 ; 97 (8): 515-31 Nephropedia Template TP {{tp|p=23716465|t=2013. Prenatal Exposure to Nitrosatable Drugs, Vitamin C, and Risk of Selected Birth Defects |pdf=|usr=}}{{23716465}} gab.com Text Prenatal Exposure to Nitrosatable Drugs, Vitamin C, and Risk of Selected Birth Defects JO: Birth Defects Res A Clin Mol Teratol http://www.kidney.de/pget.php?&tw=1&pmid=23716465 #FOAvip BACKGROUND: Nitrosatable drugs, such as secondary or tertiary amines and amides react with nitrite in an acidic environment to form N-nitroso compounds, teratogens in animal models. Vitamin C is a known nitrosation inhibitor. METHODS: Using data from the National Birth Defects Prevention Study, we assessed nitrosatable drug exposure and vitamin C intake during the first trimester among 11,606 case-mothers of infants with oral clefts, limb deficiencies (LDs), or congenital heart defects and 6807 control-mothers of infants without major birth defects during 1997?2005. Daily intake of vitamin C was estimated from maternal interviews that elicited information about supplement use and dietary intake. RESULTS: With no reported use of nitrosatable drugs as the referent group, a lower odds ratio (OR) was observed for transverse LDs among births to mothers exposed to secondary amine drugs and daily vitamin C supplementation (adjusted odds ratio [aOR] 1.2, 95% confidence interval [CI] 0.83?1.8) compared with women taking these drugs and no supplementation (aOR 2.7, 95% CI 1.5?4.6). The OR for longitudinal LDs associated with secondary amine exposure was lower with daily dietary vitamin C intake ?85 mg (aOR 1.2, 95% CI 0.68?2.0) compared with <85 mg (aOR 1.9, 95% CI 1.2?3.1). Daily vitamin C supplementation in combination with higher dietary vitamin C intake reduced associations between nitrosatable drug exposures and limb deficiencies and atrial septal defects not otherwise specified. CONCLUSION: Prenatal dietary and vitamin C supplement intake may diminish the association between nitrosatable drug exposure during pregnancy and selected birth defects. Twit Text FOAVip Prenatal Exposure to Nitrosatable Drugs, Vitamin C, and Risk of Selected Birth Defects ????Birth Defects Res A Clin Mol Teratol http://www.kidney.de/pget.php?&tw=1&pmid=23716465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23716465 #FOAvip English Wikipedia <ref>{{Cite pmid|23716465}}</ref> Prenatal Exposure to Nitrosatable Drugs, Vitamin C, and Risk of Selected Birth Defects #MMPMID23716465 Shinde MU; Vuong AM; Brender JD; Werler MM; Kelley KE; Huber JC; Sharkey JR; Zheng Q; Suarez L; Langlois PH; Canfield MA; Romitti PA; Malik S Birth Defects Res A Clin Mol Teratol 2013[Aug]; 97 (8): 515-31 PMID23716465show ga BACKGROUND: Nitrosatable drugs, such as secondary or tertiary amines and amides react with nitrite in an acidic environment to form N-nitroso compounds, teratogens in animal models. Vitamin C is a known nitrosation inhibitor. METHODS: Using data from the National Birth Defects Prevention Study, we assessed nitrosatable drug exposure and vitamin C intake during the first trimester among 11,606 case-mothers of infants with oral clefts, limb deficiencies (LDs), or congenital heart defects and 6807 control-mothers of infants without major birth defects during 1997?2005. Daily intake of vitamin C was estimated from maternal interviews that elicited information about supplement use and dietary intake. RESULTS: With no reported use of nitrosatable drugs as the referent group, a lower odds ratio (OR) was observed for transverse LDs among births to mothers exposed to secondary amine drugs and daily vitamin C supplementation (adjusted odds ratio [aOR] 1.2, 95% confidence interval [CI] 0.83?1.8) compared with women taking these drugs and no supplementation (aOR 2.7, 95% CI 1.5?4.6). The OR for longitudinal LDs associated with secondary amine exposure was lower with daily dietary vitamin C intake ?85 mg (aOR 1.2, 95% CI 0.68?2.0) compared with <85 mg (aOR 1.9, 95% CI 1.2?3.1). Daily vitamin C supplementation in combination with higher dietary vitamin C intake reduced associations between nitrosatable drug exposures and limb deficiencies and atrial septal defects not otherwise specified. CONCLUSION: Prenatal dietary and vitamin C supplement intake may diminish the association between nitrosatable drug exposure during pregnancy and selected birth defects. äPrenatal Exposure to Nitrosatable Drugs, Vitamin C, and Risk of Select(epmc).pdf DeepDyve Pubget Overpricing