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10.1016/j.conb.2017.12.008 http://scihub22266oqcxt.onion/10.1016/j.conb.2017.12.008 C5892838!5892838!29351877     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29351877&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Neurobiol 2018 ; 48 (ä): 193-200 Nephropedia Template TP {{tp|p=29351877|t=2018. REST, a master transcriptional regulator in neurodegenerative disease |pdf=|usr=}}{{29351877}} gab.com Text REST, a master transcriptional regulator in neurodegenerative disease JO: Curr Opin Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=29351877 #FOAvip The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and ?-amyloid toxicity. This review focuses on recent findings that dysregulation of REST and REST-dependent epigenetic remodeling provide a central mechanism critical to the progressive neurodegeneration associated with neurologic disorders and diseases including global ischemia, stroke, epilepsy, Alzheimer?s and Huntington?s disease. Twit Text FOAVip REST, a master transcriptional regulator in neurodegenerative disease ????Curr Opin Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=29351877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29351877 #FOAvip English Wikipedia <ref>{{Cite pmid|29351877}}</ref> REST, a master transcriptional regulator in neurodegenerative disease #MMPMID29351877 Hwang JY; Zukin RS Curr Opin Neurobiol 2018[Feb]; 48 (ä): 193-200 PMID29351877show ga The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and ?-amyloid toxicity. This review focuses on recent findings that dysregulation of REST and REST-dependent epigenetic remodeling provide a central mechanism critical to the progressive neurodegeneration associated with neurologic disorders and diseases including global ischemia, stroke, epilepsy, Alzheimer?s and Huntington?s disease. äREST, a master transcriptional regulator in neurodegenerative disease (epmc).pdf DeepDyve Pubget Overpricing