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10.1186/s13148-018-0486-z http://scihub22266oqcxt.onion/10.1186/s13148-018-0486-z C5891930!5891930 !29643943     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29643943 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Epigenetics 2018 ; 10 (ä): 47 Nephropedia Template TP {{tp|p=29643943 |t=2018. H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia |pdf=|usr=}}{{29643943 }} gab.com Text H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia JO: Clin Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=29643943 #FOAvip BACKGROUND: The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential role of H19 and its clinical significance in acute myeloid leukemia (AML) remain largely elusive. METHODS: H19 expression was detected by qPCR, and clinical significance in AML patients was further analyzed. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data for AML were used as validation cohorts. The roles of H19 in cell proliferation and apoptosis were determined by cell proliferation assay and flow cytometry analysis. RESULTS: H19 expression was significantly increased in AML patients but not associated with embedded miR-675 expression. Moreover, H19 overexpression was not dependent on the methylation pattern in H19 differentially methylated region/imprinting control region. Strong association was observed between H19 overexpression and patients' characteristics including sex, higher white blood cells, older age, and intermediate karyotype, FLT3-ITD, and DNMT3A mutations. In addition, H19 overexpression correlated with lower complete remission (CR) rate and shorter overall survival, and further confirmed by multivariate analyses. Importantly, the prognostic effect of H19 expression was validated by TCGA and GEO data. In the follow-up of patients, H19 expression in CR phase was lower than diagnosis time and returned at relapse time. Loss-of-function experiments showed that H19 exhibited anti-proliferative and pro-apoptotic effects in leukemic cell HL60. Furthermore, H19 expression was positively correlated with potential downstream gene ID2 in AML. CONCLUSIONS: Our findings revealed that methylation-independent H19 was a prognostic and predictive biomarker in AML, and H19/ID2 played crucial roles in leukemogenesis with potential therapeutic target value. Twit Text FOAVip H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia ????Clin Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=29643943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643943 #FOAvip English Wikipedia <ref>{{Cite pmid|29643943 }}</ref> H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia #MMPMID29643943 Zhang TJ ; Zhou JD ; Zhang W ; Lin J ; Ma JC ; Wen XM ; Yuan Q ; Li XX ; Xu ZJ ; Qian J Clin Epigenetics 2018[]; 10 (ä): 47 PMID29643943 show ga BACKGROUND: The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential role of H19 and its clinical significance in acute myeloid leukemia (AML) remain largely elusive. METHODS: H19 expression was detected by qPCR, and clinical significance in AML patients was further analyzed. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data for AML were used as validation cohorts. The roles of H19 in cell proliferation and apoptosis were determined by cell proliferation assay and flow cytometry analysis. RESULTS: H19 expression was significantly increased in AML patients but not associated with embedded miR-675 expression. Moreover, H19 overexpression was not dependent on the methylation pattern in H19 differentially methylated region/imprinting control region. Strong association was observed between H19 overexpression and patients' characteristics including sex, higher white blood cells, older age, and intermediate karyotype, FLT3-ITD, and DNMT3A mutations. In addition, H19 overexpression correlated with lower complete remission (CR) rate and shorter overall survival, and further confirmed by multivariate analyses. Importantly, the prognostic effect of H19 expression was validated by TCGA and GEO data. In the follow-up of patients, H19 expression in CR phase was lower than diagnosis time and returned at relapse time. Loss-of-function experiments showed that H19 exhibited anti-proliferative and pro-apoptotic effects in leukemic cell HL60. Furthermore, H19 expression was positively correlated with potential downstream gene ID2 in AML. CONCLUSIONS: Our findings revealed that methylation-independent H19 was a prognostic and predictive biomarker in AML, and H19/ID2 played crucial roles in leukemogenesis with potential therapeutic target value. |*DNA Methylation [MESH] |*Up-Regulation [MESH] |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Apoptosis [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Child [MESH] |DNA (Cytosine-5-)-Methyltransferases/genetics [MESH] |DNA Methyltransferase 3A [MESH] |Female [MESH] |Gene Expression Regulation, Leukemic [MESH] |Genetic Predisposition to Disease [MESH] |HL-60 Cells [MESH] |Humans [MESH] |Inhibitor of Differentiation Protein 2/genetics [MESH] |Leukemia, Myeloid, Acute/*genetics [MESH] |Male [MESH] |MicroRNAs/genetics [MESH] |Middle Aged [MESH] |Prognosis [MESH] |RNA, Long Noncoding/*genetics [MESH] |Survival Analysis [MESH] |Young Adult [MESH]H19 overexpression promotes leukemogenesis and predicts unfavorable pr(epmc).pdf DeepDyve Pubget Overpricing