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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Reprod+Med+Biol
2008 ; 7
(1
): 37-43
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p-Chloroamphetamine-induced rat ejaculation is not associated with the preoptic
nucleus or medial nucleus amygdala
#MMPMID29662416
Yokosuka M
; Takagi S
; Katou M
; Pudcharaporn K
; Gizurarson S
; Ichikawa M
; Saito TR
Reprod Med Biol
2008[Mar]; 7
(1
): 37-43
PMID29662416
show ga
Aim:? In the rat, intraperitoneal injection of p-chloroamphetamine (PCA), which
releases central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals,
induces ejaculation, even in the absence of an estrus female or female-related
smell information. It is well known that the medial preoptic nucleus (MPN) and
the medial nucleus amygdala (MEA) play a major role in the control of male sexual
behavior in mammals. We examined whether or not neuronal activity of the MPN
and/or the MEA was associated with PCA-induced ejaculation. Methods:? Using c-Fos
immunohistochemistry, we demonstrated a difference in the neural activities of
the MPN and the MEA for ejaculation during copulation with an estrus female and
ejaculation by PCA injection. Results:? Increased numbers of c-Fos-immunoreactive
(c-Fos-IR) cells were found in the MPN and the MEA in the brains of the mating
animals, whereas in the brains of the animals undergoing PCA-induced ejaculation
there was no increase in the number of c-Fos-IR cells in the MPN and a small
increase in the MEA. Conclusion:? Based on these results, ejaculation induced by
PCA is not associated with the MPN. Moreover, the MEA is not the main act for
this ejaculation. (Reprod Med Biol 2008; 7: 37-43).