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2018 ; 109
(4
): 980-987
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Epirubicin suppresses proliferative and metastatic potential by downregulating
transforming growth factor-?-induced expression in urothelial carcinoma
#MMPMID28940965
Shang D
; Song B
; Liu Y
Cancer Sci
2018[Apr]; 109
(4
): 980-987
PMID28940965
show ga
Transforming growth factor-?-induced (TGF?I) is considered to be a vital gene in
several carcinomas. In this study we determined the effect of TGFBI on the
proliferative and metastatic potential of human urothelial carcinoma (UC) cells
as well as its mRNA and protein expression, which were detected by RT-PCR and
western blot, respectively. UC cell proliferation was analyzed by WST-1 assay and
Hoechst 33258 staining. The effect of TGFBI on UC cell metastasis was analyzed
using adhesion, migration and invasion assays. We found that TGFBI increased the
proliferation of UC cells. Moreover, TGFBI enhanced the adhesion, migration and
invasion of UC cells by upregulating MMP-2, MMP-9 and calpain-2 expression. We
evaluated the effect of Epirubicin (EPI) on the regulation of TGFBI expression
and found that TGFBI acts as a downstream target of EPI and is suppressed by EPI
in UC cells. EPI is more effective in inhibiting the proliferation and metastasis
of UC cells with high TGFBI expression. This study demonstrates that TGFBI might
lead to tumorigenesis and progression of UC and those cells with high TGFBI
expression may be vulnerable to relapse. EPI could prove to be a therapeutic
option in patients with high TGFBI expressing UC cells.
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