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10.1111/cas.13551 http://scihub22266oqcxt.onion/10.1111/cas.13551 C5891186!5891186!29478262     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2018 ; 109 (4): 919-25 Nephropedia Template TP {{tp|p=29478262|t=2018. Roles of protein kinase R in cancer: Potential as a therapeutic target |pdf=|usr=}}{{29478262}} gab.com Text Roles of protein kinase R in cancer: Potential as a therapeutic target JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=29478262 #FOAvip Double?stranded (ds) RNA?dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein induced by interferon (IFN) and activated by dsRNA. PKR is recognized as a key executor of antiviral host defense. Moreover, it contributes to inflammation and immune regulation through several signaling pathways. In addition to IFN and dsRNA, PKR is activated by multiple stimuli and regulates various signaling pathways including the mitogen?activated protein kinase (MAPK) and nuclear factor kappa?light?chain?enhancer of activated B cells pathways. PKR was initially thought to be a tumor suppressor as a result of its ability to suppress cell growth and interact with major tumor suppressor genes. However, in several types of malignant disease, such as colon and breast cancers, its role remains controversial. In hepatocellular carcinoma, hepatitis C virus (HCV) is the main cause of liver cancer, and PKR inhibits HCV replication, indicating its role as a tumor suppressor. However, PKR is overexpressed in cirrhotic patients, and acts as a tumor promoter through enhancement of cancer cell growth by mediating MAPK or signal transducer and activator of transcription pathways. Moreover, PKR is reportedly required for the activation of inflammasomes and influences metabolic disorders. In the present review, we introduce the multifaceted roles of PKR such as antiviral function, tumor cell growth, regulation of inflammatory immune responses, and maintaining metabolic homeostasis; and discuss future perspectives on PKR biology including its potential as a therapeutic target for liver cancer. Twit Text FOAVip Roles of protein kinase R in cancer: Potential as a therapeutic target ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=29478262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29478262 #FOAvip English Wikipedia <ref>{{Cite pmid|29478262}}</ref> Roles of protein kinase R in cancer: Potential as a therapeutic target #MMPMID29478262 Watanabe T; Imamura T; Hiasa Y Cancer Sci 2018[Apr]; 109 (4): 919-25 PMID29478262show ga Double?stranded (ds) RNA?dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein induced by interferon (IFN) and activated by dsRNA. PKR is recognized as a key executor of antiviral host defense. Moreover, it contributes to inflammation and immune regulation through several signaling pathways. In addition to IFN and dsRNA, PKR is activated by multiple stimuli and regulates various signaling pathways including the mitogen?activated protein kinase (MAPK) and nuclear factor kappa?light?chain?enhancer of activated B cells pathways. PKR was initially thought to be a tumor suppressor as a result of its ability to suppress cell growth and interact with major tumor suppressor genes. However, in several types of malignant disease, such as colon and breast cancers, its role remains controversial. In hepatocellular carcinoma, hepatitis C virus (HCV) is the main cause of liver cancer, and PKR inhibits HCV replication, indicating its role as a tumor suppressor. However, PKR is overexpressed in cirrhotic patients, and acts as a tumor promoter through enhancement of cancer cell growth by mediating MAPK or signal transducer and activator of transcription pathways. Moreover, PKR is reportedly required for the activation of inflammasomes and influences metabolic disorders. In the present review, we introduce the multifaceted roles of PKR such as antiviral function, tumor cell growth, regulation of inflammatory immune responses, and maintaining metabolic homeostasis; and discuss future perspectives on PKR biology including its potential as a therapeutic target for liver cancer. äRoles of protein kinase R in cancer: Potential as a therapeutic target(epmc).pdf DeepDyve Pubget Overpricing