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10.1038/nchem.2778 http://scihub22266oqcxt.onion/10.1038/nchem.2778 C5890907!5890907!28937680     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem 2017 ; 9 (10): 1025-33 Nephropedia Template TP {{tp|p=28937680|t=2017. Salinomycin kills cancer stem cells by sequestering iron in lysosomes |pdf=|usr=}}{{28937680}} gab.com Text Salinomycin kills cancer stem cells by sequestering iron in lysosomes JO: Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=28937680 #FOAvip Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal and tumour seeding capacity. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a selective agent against CSCs through mechanisms that remain elusive. Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, accumulates and sequesters iron in lysosomes. In response to the ensuing cytoplasmic depletion of iron, cells triggered the degradation of ferritin in lysosomes, leading to further iron loading in this organelle. Iron-mediated production of reactive oxygen species promoted lysosomal membrane permeabilization, activating a cell death pathway consistent with ferroptosis. These findings reveal the prevalence of iron homeostasis in breast CSCs, pointing towards iron and iron-mediated processes as potential targets against these cells. Twit Text FOAVip Salinomycin kills cancer stem cells by sequestering iron in lysosomes ????Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=28937680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28937680 #FOAvip English Wikipedia <ref>{{Cite pmid|28937680}}</ref> Salinomycin kills cancer stem cells by sequestering iron in lysosomes #MMPMID28937680 Mai TT; Hamaï A; Hienzsch A; Cañeque T; Müller S; Wicinski J; Cabaud O; Leroy C; David A; Acevedo V; Ryo A; Ginestier C; Birnbaum D; Charafe-Jauffret E; Codogno P; Mehrpour M; Rodriguez R Nat Chem 2017[Oct]; 9 (10): 1025-33 PMID28937680show ga Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal and tumour seeding capacity. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a selective agent against CSCs through mechanisms that remain elusive. Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, accumulates and sequesters iron in lysosomes. In response to the ensuing cytoplasmic depletion of iron, cells triggered the degradation of ferritin in lysosomes, leading to further iron loading in this organelle. Iron-mediated production of reactive oxygen species promoted lysosomal membrane permeabilization, activating a cell death pathway consistent with ferroptosis. These findings reveal the prevalence of iron homeostasis in breast CSCs, pointing towards iron and iron-mediated processes as potential targets against these cells. äSalinomycin kills cancer stem cells by sequestering iron in lysosomes (epmc).pdf DeepDyve Pubget Overpricing