Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Metab 2017 ; 26 (1): 17-23 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Is Type-2 Diabetes a Glycogen Storage Disease of Pancreatic ?-Cells? #MMPMID28683284
Ashcroft FM; Rohm M; Clark A; Brereton MF
Cell Metab 2017[Jul]; 26 (1): 17-23 PMID28683284show ga
Elevated plasma glucose leads to pancreatic ?-cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this ?glucotoxicity? via dysregulated biochemical pathways promoting ?-cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in ?-cells in normoglycaemia and in diabetes.