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10.1016/j.cmet.2017.05.014

http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.05.014
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C5890904!5890904!28683284
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suck abstract from ncbi


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pmid28683284      Cell+Metab 2017 ; 26 (1): 17-23
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  • Is Type-2 Diabetes a Glycogen Storage Disease of Pancreatic ?-Cells? #MMPMID28683284
  • Ashcroft FM; Rohm M; Clark A; Brereton MF
  • Cell Metab 2017[Jul]; 26 (1): 17-23 PMID28683284show ga
  • Elevated plasma glucose leads to pancreatic ?-cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this ?glucotoxicity? via dysregulated biochemical pathways promoting ?-cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in ?-cells in normoglycaemia and in diabetes.
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