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10.1136/lupus-2017-000252

http://scihub22266oqcxt.onion/10.1136/lupus-2017-000252
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suck abstract from ncbi


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pmid29644080
      Lupus+Sci+Med 2018 ; 5 (1 ): e000252
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  • Safety, tolerability and pharmacokinetics of subcutaneous and intravenous anifrolumab in healthy volunteers #MMPMID29644080
  • Tummala R ; Rouse T ; Berglind A ; Santiago L
  • Lupus Sci Med 2018[]; 5 (1 ): e000252 PMID29644080 show ga
  • OBJECTIVES: To compare the pharmacokinetics (PK), safety and tolerability of subcutaneous (SC) and intravenous anifrolumab, an anti-type I interferon receptor monoclonal antibody in development for SLE, in healthy volunteers. METHODS: In this Phase I randomised, placebo-controlled study, 30 adults were assigned to three treatment cohorts (anifrolumab 300?mg SC (n=6), anifrolumab 300?mg intravenous (n=6), anifrolumab 600?mg SC (n=6)) and placebo (n=4/cohort). Serial blood samples were collected up to Day 84 to measure anifrolumab concentrations and antidrug antibodies (ADAs). PK parameters were estimated by noncompartmental analysis. RESULTS: Maximum serum concentrations in SC cohorts occurred after 4-7 days. Anifrolumab serum concentrations were below the limit of detection in all individuals by Day 84. Exposure to SC anifrolumab increased dose proportionally from 300?mg to 600?mg based on area under the serum concentration-time curve. Anifrolumab 300?mg SC exposure reached 87% of the intravenous exposure. Anifrolumab 300?mg SC and placebo administration elicited minimal injection-site reactions. Transient injection-site induration occurred in five of six individuals after anifrolumab 600?mg SC and two of four individuals after placebo. Transient, mild to moderate injection-site induration and pruritus occurred simultaneously in two of six individuals after anifrolumab 600?mg SC. Adverse events were reported by 50% (n=9) of anifrolumab-treated individuals and 33% (n=4) of placebo-treated individuals. ADAs were detected in only one individual in the anifrolumab 300-mg intravenous group at the Day 84 assessment. CONCLUSION: Anifrolumab 300-mg SC exposure was 87% of intravenous administration, with single SC anifrolumab administrations well tolerated in healthy volunteers.
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