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10.1038/s41467-018-03753-4 http://scihub22266oqcxt.onion/10.1038/s41467-018-03753-4 C5890293!5890293 !29632300     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29632300 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 1344 Nephropedia Template TP {{tp|p=29632300 |t=2018. Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury |pdf=|usr=}}{{29632300 }} gab.com Text Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29632300 #FOAvip Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial tubular cell loss. Cell cycle and ploidy analysis upon AKI in conditional Pax8/FUCCI2aR mice and human biopsies identify endocycle-mediated hypertrophy of tubular cells. By contrast, a small subset of Pax2+ tubular progenitors enriches via higher stress resistance and clonal expansion and regenerates necrotic tubule segments, a process that can be enhanced by suitable drugs. Thus,  renal functional recovery upon AKI involves remnant tubular cell hypertrophy via endocycle and limited progenitor-driven regeneration that can be pharmacologically enhanced. Twit Text FOAVip Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29632300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632300 #FOAvip English Wikipedia <ref>{{Cite pmid|29632300 }}</ref> Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury #MMPMID29632300 Lazzeri E ; Angelotti ML ; Peired A ; Conte C ; Marschner JA ; Maggi L ; Mazzinghi B ; Lombardi D ; Melica ME ; Nardi S ; Ronconi E ; Sisti A ; Antonelli G ; Becherucci F ; De Chiara L ; Guevara RR ; Burger A ; Schaefer B ; Annunziato F ; Anders HJ ; Lasagni L ; Romagnani P Nat Commun 2018[Apr]; 9 (1 ): 1344 PMID29632300 show ga Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial tubular cell loss. Cell cycle and ploidy analysis upon AKI in conditional Pax8/FUCCI2aR mice and human biopsies identify endocycle-mediated hypertrophy of tubular cells. By contrast, a small subset of Pax2+ tubular progenitors enriches via higher stress resistance and clonal expansion and regenerates necrotic tubule segments, a process that can be enhanced by suitable drugs. Thus,  renal functional recovery upon AKI involves remnant tubular cell hypertrophy via endocycle and limited progenitor-driven regeneration that can be pharmacologically enhanced. |Acute Kidney Injury/genetics/*pathology/*physiopathology [MESH] |Adult Stem Cells/pathology [MESH] |Animals [MESH] |Cell Cycle [MESH] |Cell Dedifferentiation [MESH] |Cell Enlargement [MESH] |Cell Lineage [MESH] |Epithelial Cells/drug effects/pathology [MESH] |Female [MESH] |Histone Deacetylase Inhibitors/pharmacology [MESH] |Humans [MESH] |Kidney Tubules/drug effects/pathology/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |PAX2 Transcription Factor/metabolism [MESH] |PAX8 Transcription Factor/metabolism [MESH] |Ploidies [MESH] |Regeneration/drug effects [MESH]Endocycle-related tubular cell hypertrophy and progenitor proliferatio(epmc).pdf DeepDyve Pubget Overpricing