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Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis
Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
in Lung Cancer
#MMPMID29662483
Tian X
; Ma J
; Wang T
; Tian J
; Zhang Y
; Mao L
; Xu H
; Wang S
Front Immunol
2018[]; 9
(?): 473
PMID29662483
show ga
HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding
RNA that has been shown to be a key regulator of myeloid cell development by
targeting HOXA1. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous
population of immature myeloid cells that possess immunosuppressive function.
However, the impact of HOTAIRM1 on the development of MDSCs remains unknown. In
this study, we demonstrated that HOTAIRM1 was expressed in MDSCs and that
overexpression of HOTAIRM1 could downregulate the expression of suppressive
molecules in MDSCs. In addition, HOTAIRM1 levels were observed to be decreased in
the peripheral blood cells of lung cancer patients compared with those of healthy
controls. By analyzing HOTAIRM1 expression levels in different types of lung
cancer, we found that HOTAIRM1 was mainly expressed in lung adenocarcinoma.
Finally, it was confirmed that HOTAIRM1 could enhance the expression of HOXA1 in
MDSCs and that high levels of HOXA1, the target gene of HOTAIRM1, could delay
tumor progression and enhance the antitumor immune response by downregulating the
immunosuppression of MDSCs. Taken together, this study illustrates that
HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a
potential therapeutic target in lung cancer.
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