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10.1016/j.cmet.2016.09.005 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.09.005 C5889952!5889952!27746051     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2016 ; 24 (5): 728-39 Nephropedia Template TP {{tp|p=27746051|t=2016. Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers |pdf=|usr=}}{{27746051}} gab.com Text Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27746051 #FOAvip Repurposing metformin for cancer therapy is attractive due to its safety profile, epidemiological evidence, and encouraging data from human clinical trials. Although it is known to systemically affect glucose metabolism in liver, muscle, gut, and other tissues, the molecular determinants that predict a patient response in cancer remain unknown. Here we carry out an integrative metabolomics analysis of metformin action in ovarian cancer. Metformin accumulated in patient biopsies and pathways involving nucleotide metabolism, redox and energy status, all related to mitochondrial metabolism, were affected in treated tumors. Strikingly a metabolic signature obtained in a patient with an exceptional clinical outcome mirrored that of a responsive animal tumor. Mechanistically, we demonstrate with stable isotope tracing that these metabolic signatures are due to an inability to adapt nutrient utilization in the mitochondria. This analysis provides new insights into mitochondrial metabolism and may lead to more precise indications of metformin in cancer. Twit Text FOAVip Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27746051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27746051 #FOAvip English Wikipedia <ref>{{Cite pmid|27746051}}</ref> Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers #MMPMID27746051 Liu X; Romero IL; Litchfield LM; Lengyel E; Locasale JW Cell Metab 2016[Nov]; 24 (5): 728-39 PMID27746051show ga Repurposing metformin for cancer therapy is attractive due to its safety profile, epidemiological evidence, and encouraging data from human clinical trials. Although it is known to systemically affect glucose metabolism in liver, muscle, gut, and other tissues, the molecular determinants that predict a patient response in cancer remain unknown. Here we carry out an integrative metabolomics analysis of metformin action in ovarian cancer. Metformin accumulated in patient biopsies and pathways involving nucleotide metabolism, redox and energy status, all related to mitochondrial metabolism, were affected in treated tumors. Strikingly a metabolic signature obtained in a patient with an exceptional clinical outcome mirrored that of a responsive animal tumor. Mechanistically, we demonstrate with stable isotope tracing that these metabolic signatures are due to an inability to adapt nutrient utilization in the mitochondria. This analysis provides new insights into mitochondrial metabolism and may lead to more precise indications of metformin in cancer. äMetformin targets central carbon metabolism and reveals mitochondrial (epmc).pdf DeepDyve Pubget Overpricing