Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology,
and therapy with a focus on vascular disease
#MMPMID28258130
Schivo M
; Albertson TE
; Haczku A
; Kenyon NJ
; Zeki AA
; Kuhn BT
; Louie S
; Avdalovic MV
J Investig Med
2017[Aug]; 65
(6
): 953-963
PMID28258130
show ga
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous
syndrome that represents a major global health burden. COPD phenotypes have
recently emerged based on large cohort studies addressing the need to better
characterize the syndrome. Though comprehensive phenotyping is still at an early
stage, factors such as ethnicity and radiographic, serum, and exhaled breath
biomarkers have shown promise. COPD is also an immunological disease where innate
and adaptive immune responses to the environment and tobacco smoke are altered.
The frequent overlap between COPD and other systemic diseases, such as
cardiovascular disease, has influenced COPD therapy, and treatments for both
conditions may lead to improved patient outcomes. Here, we discuss current
paradigms that center on improving the definition of COPD, understanding the
immunological overlap between COPD and vascular inflammation, and the treatment
of COPD-with a focus on comorbid cardiovascular disease.
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