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2018 ; 2018
(ä): 6319649
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Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic
Targeting in Lung Cancer
#MMPMID29765990
Ma J
; Xu H
; Wang S
J Immunol Res
2018[]; 2018
(ä): 6319649
PMID29765990
show ga
Lung cancer is the leading cause of cancer death worldwide due to its late
diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging
and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs)
are the main tumor suppressor factors, and the treatment strategy of targeting
MDSCs is gradually emerging. In this review, we summarize what is currently known
about the role of MDSCs in lung cancer. In view of the emerging importance of
MDSCs in lung cancer, the treatment of targeting MDSCs will be useful to the
control of the development and progression of lung cancer. However, the
occurrence, metastasis, and survival of cancer is the result of multiple factors
and multiple mechanisms, so combined treatments using different strategies will
become the major therapy method for lung cancer in the future.