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10.3748/wjg.v24.i13.1373 http://scihub22266oqcxt.onion/10.3748/wjg.v24.i13.1373 C5889818!5889818!29632419     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2018 ; 24 (13): 1373-85 Nephropedia Template TP {{tp|p=29632419|t=2018. Dissecting the molecular pathophysiology of drug-induced liver injury |pdf=|usr=}}{{29632419}} gab.com Text Dissecting the molecular pathophysiology of drug-induced liver injury JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=29632419 #FOAvip Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. Twit Text FOAVip Dissecting the molecular pathophysiology of drug-induced liver injury ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=29632419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632419 #FOAvip English Wikipedia <ref>{{Cite pmid|29632419}}</ref> Dissecting the molecular pathophysiology of drug-induced liver injury #MMPMID29632419 Ye H; Nelson LJ; Gómez del Moral M; Martínez-Naves E; Cubero FJ World J Gastroenterol 2018[Apr]; 24 (13): 1373-85 PMID29632419show ga Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. äDissecting the molecular pathophysiology of drug-induced liver injury (epmc).pdf DeepDyve Pubget Overpricing