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2018 ; 33
(3
): 335-349
Nephropedia Template TP
gab.com Text
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English Wikipedia
The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a
cohort from 12 European countries
#MMPMID29497894
Grabow D
; Kaiser M
; Hjorth L
; Byrne J
; Alessi D
; Allodji RS
; Bagnasco F
; Bárdi E
; Bautz A
; Bright CJ
; de Vathaire F
; Feijen EAM
; Garwicz S
; Hagberg O
; Haupt R
; Hawkins MM
; Jakab Z
; Kremer LCM
; Kuehni CE
; Kuonen R
; Lähteenmäki PM
; Reulen RC
; Ronckers CM
; Sacerdote C
; Vu-Bezin G
; Wesenberg F
; Wiebe T
; Winter DL
; Winther JF
; Zaletel LZ
; Kaatsch P
Eur J Epidemiol
2018[Mar]; 33
(3
): 335-349
PMID29497894
show ga
Childhood cancer survivors face risks from a variety of late effects, including
cardiac events, second cancers, and late mortality. The aim of the pan-European
PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies
(PanCareSurFup) Consortium was to collect data on incidence and risk factors for
these late effects among childhood cancer survivors in Europe. This paper
describes the methodology of the data collection for the overall PanCareSurFup
cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from
12 countries delivered data to the data centre in Mainz. Data providers used a
single variable list that covered all three outcomes. After validity and
plausibility checks data was provided to the outcome-specific working groups. In
total, we collected data on 115,596 patients diagnosed with cancer from 1940 to
2011, of whom 83,333 had survived 5 years or more. Due to the eligibility
criteria and other requirements different numbers of survivors were eligible for
the analysis of each of the outcomes. Thus, 1014 patients with at least one
cardiac event were identified from a cohort of 39,152 5-year survivors; for
second cancers 3995 survivors developed at least one second cancer from a cohort
of 71,494 individuals, and from the late mortality cohort of 79,441 who had
survived at least 5 years, 9247 died subsequently. Through the close cooperation
of many European countries and the establishment of one central data collection
and harmonising centre, the project succeeded in generating the largest cohort of
children with cancer to date.
|*Registries/statistics & numerical data
[MESH]
|Adolescent
[MESH]
|Cancer Survivors/*statistics & numerical data
[MESH]