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10.1073/pnas.1719298115 http://scihub22266oqcxt.onion/10.1073/pnas.1719298115 C5889649!5889649!29555767     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (14): 3646-51 Nephropedia Template TP {{tp|p=29555767|t=2018. ASK family kinases mediate cellular stress and redox signaling to circadian clock |pdf=|usr=}}{{29555767}} gab.com Text ASK family kinases mediate cellular stress and redox signaling to circadian clock JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29555767 #FOAvip The cellular stress response and circadian clock system are fundamental functions in homeostatic regulation in almost all organisms. However, whether these two mechanisms are interlocked with each other, and the key molecule that links cellular stress and the circadian clock, remain unclear. Here we identify ASK family kinases that are essential for the circadian clock to respond to cellular stress, and report that Ask1 transcription is rhythmically controlled by the circadian clock. Moreover, LC-MS/MS?based proteomic analysis provides insight into a molecular mechanism in which dephosphorylation-triggered changes to the ASK complex mediate cellular stress to the circadian clock. From the perspective of cell signaling, our present findings expand previously reported roles of stress signaling toward regulation of the circadian clock. Twit Text FOAVip ASK family kinases mediate cellular stress and redox signaling to circadian clock ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29555767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29555767 #FOAvip English Wikipedia <ref>{{Cite pmid|29555767}}</ref> ASK family kinases mediate cellular stress and redox signaling to circadian clock #MMPMID29555767 Imamura K; Yoshitane H; Hattori K; Yamaguchi M; Yoshida K; Okubo T; Naguro I; Ichijo H; Fukada Y Proc Natl Acad Sci U S A 2018[Apr]; 115 (14): 3646-51 PMID29555767show ga The cellular stress response and circadian clock system are fundamental functions in homeostatic regulation in almost all organisms. However, whether these two mechanisms are interlocked with each other, and the key molecule that links cellular stress and the circadian clock, remain unclear. Here we identify ASK family kinases that are essential for the circadian clock to respond to cellular stress, and report that Ask1 transcription is rhythmically controlled by the circadian clock. Moreover, LC-MS/MS?based proteomic analysis provides insight into a molecular mechanism in which dephosphorylation-triggered changes to the ASK complex mediate cellular stress to the circadian clock. From the perspective of cell signaling, our present findings expand previously reported roles of stress signaling toward regulation of the circadian clock. äASK family kinases mediate cellular stress and redox signaling to circ(epmc).pdf DeepDyve Pubget Overpricing