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10.1016/j.biopen.2016.05.001 http://scihub22266oqcxt.onion/10.1016/j.biopen.2016.05.001 C5889486!5889486!29632840     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Open 2016 ; 2 (ä): 69-78 Nephropedia Template TP {{tp|p=29632840|t=2016. The proto-oncogenic protein TAL1 controls TGF-?1 signaling through interaction with SMAD3 |pdf=|usr=}}{{29632840}} gab.com Text The proto-oncogenic protein TAL1 controls TGF- 1 signaling through interaction with SMAD3 JO: Biochim Open http://www.kidney.de/pget.php?&tw=1&pmid=29632840 #FOAvip TGF-?1 is involved in many aspects of tissue development and homeostasis including hematopoiesis. The TAL1 transcription factor is also an important player of this latter process and is expressed very early in the myeloid and erythroid lineages. We previously established a link between TGF-?1 signaling and TAL1 by showing that the cytokine was able to induce its proteolytic degradation by the ubiquitin proteasome pathway. In this manuscript we show that TAL1 interacts with SMAD3 that acts in the pathway downstream of TGF-?1 association with its receptor. TAL1 expression strengthens the positive or negative effect of SMAD3 on various genes. Both transcription factors activate the inhibitory SMAD7 factor through the E box motif present in its transcriptional promoter. DNA precipitation assays showed that TAL1 present in Jurkat or K562 cells binds to this SMAD binding element in a SMAD3 dependent manner. SMAD3 and TAL1 also inhibit several genes including ID1, hTERT and TGF-?1 itself. In this latter case TAL1 and SMAD3 can impair the positive effect exerted by E47. Our results indicate that TAL1 expression can modulate TGF-?1 signaling by interacting with SMAD3 and by increasing its transcriptional properties. They also suggest the existence of a negative feedback loop between TAL1 expression and TGF-?1 signaling. Twit Text FOAVip The proto-oncogenic protein TAL1 controls TGF- 1 signaling through interaction with SMAD3 ????Biochim Open http://www.kidney.de/pget.php?&tw=1&pmid=29632840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632840 #FOAvip English Wikipedia <ref>{{Cite pmid|29632840}}</ref> The proto-oncogenic protein TAL1 controls TGF-?1 signaling through interaction with SMAD3 #MMPMID29632840 Terme JM; Lemaire S; Auboeuf D; Mocquet V; Jalinot P Biochim Open 2016[Jun]; 2 (ä): 69-78 PMID29632840show ga TGF-?1 is involved in many aspects of tissue development and homeostasis including hematopoiesis. The TAL1 transcription factor is also an important player of this latter process and is expressed very early in the myeloid and erythroid lineages. We previously established a link between TGF-?1 signaling and TAL1 by showing that the cytokine was able to induce its proteolytic degradation by the ubiquitin proteasome pathway. In this manuscript we show that TAL1 interacts with SMAD3 that acts in the pathway downstream of TGF-?1 association with its receptor. TAL1 expression strengthens the positive or negative effect of SMAD3 on various genes. Both transcription factors activate the inhibitory SMAD7 factor through the E box motif present in its transcriptional promoter. DNA precipitation assays showed that TAL1 present in Jurkat or K562 cells binds to this SMAD binding element in a SMAD3 dependent manner. SMAD3 and TAL1 also inhibit several genes including ID1, hTERT and TGF-?1 itself. In this latter case TAL1 and SMAD3 can impair the positive effect exerted by E47. Our results indicate that TAL1 expression can modulate TGF-?1 signaling by interacting with SMAD3 and by increasing its transcriptional properties. They also suggest the existence of a negative feedback loop between TAL1 expression and TGF-?1 signaling. äThe proto-oncogenic protein TAL1 controls TGF-?1 signaling through int(epmc).pdf DeepDyve Pubget Overpricing