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10.1080/2162402X.2017.1408747 http://scihub22266oqcxt.onion/10.1080/2162402X.2017.1408747 C5889288!5889288!29632720     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2018 ; 7 (4): ä Nephropedia Template TP {{tp|p=29632720|t=2018. Blockade of Tumor-Expressed PD-1 promotes lung cancer growth |pdf=|usr=}}{{29632720}} gab.com Text Blockade of Tumor-Expressed PD-1 promotes lung cancer growth JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=29632720 #FOAvip Anti-PD-1 immunotherapy is the standard of care for treating many patients with non-small cell lung cancer (NSCLC), yet mechanisms of treatment failure are emerging. We present a case of NSCLC, who rapidly progressed during a trial (NCT02318771) combining palliative radiotherapy and pembrolizumab. Planned tumor biopsy demonstrated PD-1 expression by NSCLC cells. We validated this observation by detecting PD-1 transcript in lung cancer cells and by co-localizing PD-1 and lung cancer-specific markers in resected lung cancer tissues. We further investigated the biological role of cancer-intrinsic PD-1 in a mouse lung cancer cell line, M109. Knockout or antibody blockade of PD-1 enhanced M109 viability in-vitro, while PD-1 overexpression and exposure to recombinant PD-L1 diminished viability. PD-1 blockade accelerated growth of M109-xenograft tumors with increased proliferation and decreased apoptosis in immune-deficient mice. This represents a first-time report of NSCLC-intrinsic PD-1 expression and a potential mechanism by which PD-1 blockade may promote cancer growth. Twit Text FOAVip Blockade of Tumor-Expressed PD-1 promotes lung cancer growth ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=29632720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632720 #FOAvip English Wikipedia <ref>{{Cite pmid|29632720}}</ref> Blockade of Tumor-Expressed PD-1 promotes lung cancer growth #MMPMID29632720 Du S; McCall N; Park K; Guan Q; Fontina P; Ertel A; Zhan T; Dicker AP; Lu B Oncoimmunology 2018[]; 7 (4): ä PMID29632720show ga Anti-PD-1 immunotherapy is the standard of care for treating many patients with non-small cell lung cancer (NSCLC), yet mechanisms of treatment failure are emerging. We present a case of NSCLC, who rapidly progressed during a trial (NCT02318771) combining palliative radiotherapy and pembrolizumab. Planned tumor biopsy demonstrated PD-1 expression by NSCLC cells. We validated this observation by detecting PD-1 transcript in lung cancer cells and by co-localizing PD-1 and lung cancer-specific markers in resected lung cancer tissues. We further investigated the biological role of cancer-intrinsic PD-1 in a mouse lung cancer cell line, M109. Knockout or antibody blockade of PD-1 enhanced M109 viability in-vitro, while PD-1 overexpression and exposure to recombinant PD-L1 diminished viability. PD-1 blockade accelerated growth of M109-xenograft tumors with increased proliferation and decreased apoptosis in immune-deficient mice. This represents a first-time report of NSCLC-intrinsic PD-1 expression and a potential mechanism by which PD-1 blockade may promote cancer growth. äBlockade of Tumor-Expressed PD-1 promotes lung cancer growth (epmc).pdf DeepDyve Pubget Overpricing