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10.1038/nrm.2017.104

http://scihub22266oqcxt.onion/10.1038/nrm.2017.104
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C5889127!5889127!29138516
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suck abstract from ncbi


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pmid29138516      Nat+Rev+Mol+Cell+Biol 2018 ; 19 (3): 143-57
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  • The functions and unique features of long intergenic non-coding RNA #MMPMID29138516
  • Ransohoff JD; Wei Y; Khavari PA
  • Nat Rev Mol Cell Biol 2018[Mar]; 19 (3): 143-57 PMID29138516show ga
  • Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.
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