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10.1016/j.freeradbiomed.2017.09.011 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2017.09.011 C5889093!5889093!28939422     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Free+Radic+Biol+Med 2017 ; 113 (ä): 48-58 Nephropedia Template TP {{tp|p=28939422|t=2017. Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation |pdf=|usr=}}{{28939422}} gab.com Text Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28939422 #FOAvip Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS. Here, we postulate whether, along with ROS activating Nrf2, NADPH oxidase components also participate in direct activation of Nrf2, contributing to protection from ROS. Our results show that the p47phox of the NADPH oxidase, but not p65phox or p40phox, physically binds to Nrf2, activating the Nrf2 function. p47phox binding to Nrf2/Keap1 complex suppresses the ubiquitination of Nrf2, while p47phox becomes ubiquitinated by Keap1. p47phox increases the nuclear translocation of Nrf2 and the expression of Nrf2-dependent genes, whereas genetic ablation of p47phox decreases the expression of those genes. In a lipopolysaccharide-induced acute lung inflammation mouse model, selective expression of p47phox in mouse lungs induces the expression of Nrf2-dependent genes and is sufficient to suppress neutrophilic lung inflammation. Therefore, our findings suggest that p47phox is a novel regulator of Nrf2 function. Twit Text FOAVip Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28939422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28939422 #FOAvip English Wikipedia <ref>{{Cite pmid|28939422}}</ref> Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation #MMPMID28939422 Kim KH; Sadikot RT; Lee JY; Jeong HS; Oh YK; Blackwell TS; Joo M Free Radic Biol Med 2017[Dec]; 113 (ä): 48-58 PMID28939422show ga Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS. Here, we postulate whether, along with ROS activating Nrf2, NADPH oxidase components also participate in direct activation of Nrf2, contributing to protection from ROS. Our results show that the p47phox of the NADPH oxidase, but not p65phox or p40phox, physically binds to Nrf2, activating the Nrf2 function. p47phox binding to Nrf2/Keap1 complex suppresses the ubiquitination of Nrf2, while p47phox becomes ubiquitinated by Keap1. p47phox increases the nuclear translocation of Nrf2 and the expression of Nrf2-dependent genes, whereas genetic ablation of p47phox decreases the expression of those genes. In a lipopolysaccharide-induced acute lung inflammation mouse model, selective expression of p47phox in mouse lungs induces the expression of Nrf2-dependent genes and is sufficient to suppress neutrophilic lung inflammation. Therefore, our findings suggest that p47phox is a novel regulator of Nrf2 function. äSuppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activ(epmc).pdf DeepDyve Pubget Overpricing