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2018 ; 4
(1
): vey008
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cameroonian fruit bats harbor divergent viruses, including rotavirus H,
bastroviruses, and picobirnaviruses using an alternative genetic code
#MMPMID29644096
Yinda CK
; Ghogomu SM
; Conceição-Neto N
; Beller L
; Deboutte W
; Vanhulle E
; Maes P
; Van Ranst M
; Matthijnssens J
Virus Evol
2018[Jan]; 4
(1
): vey008
PMID29644096
show ga
Most human emerging infectious diseases originate from wildlife and bats are a
major reservoir of viruses, a few of which have been highly pathogenic to humans.
In some regions of Cameroon, bats are hunted and eaten as a delicacy. This close
proximity between human and bats provides ample opportunity for zoonotic events.
To elucidate the viral diversity of Cameroonian fruit bats, we collected and
metagenomically screened eighty-seven fecal samples of Eidolon helvum and
Epomophorus gambianus fruit bats. The results showed a plethora of known and
novel viruses. Phylogenetic analyses of the eleven gene segments of the first
complete bat rotavirus H genome, showed clearly separated clusters of human,
porcine, and bat rotavirus H strains, not indicating any recent interspecies
transmission events. Additionally, we identified and analyzed a bat bastrovirus
genome (a novel group of recently described viruses, related to astroviruses and
hepatitis E viruses), confirming their recombinant nature, and provide further
evidence of additional recombination events among bat bastroviruses.
Interestingly, picobirnavirus-like RNA-dependent RNA polymerase gene segments
were identified using an alternative mitochondrial genetic code, and further
principal component analyses suggested that they may have a similar lifestyle to
mitoviruses, a group of virus-like elements known to infect the mitochondria of
fungi. Although identified bat coronavirus, parvovirus, and cyclovirus strains
belong to established genera, most of the identified partitiviruses and
densoviruses constitute putative novel genera in their respective families.
Finally, the results of the phage community analyses of these bats indicate a
very diverse geographically distinct bat phage population, probably reflecting
different diets and gut bacterial ecosystems.