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10.12659/MSM.909450 http://scihub22266oqcxt.onion/10.12659/MSM.909450 C5887685!5887685 !29588438     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29588438 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429 |pdf=|usr=}}{{29588438 }} gab.com Text Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429 JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=29588438 #FOAvip BACKGROUND: It is well known that long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely correlated with the tumorigenesis of multiple cancers, including renal cell carcinoma (RCC). However, the potential functional mechanism is still elusive. MATERIAL/METHODS: In our present research, quantitative real-time polymerase chain reaction (qRT-PCR) was performed for the measurement of MALAT1 and miR-429. CCK-8 assay and Transwell assay were performed for the proliferation, migration, and invasion abilities of RCC cells. Dual-luciferase reporter assay was performed to validate the interaction within MALAT1 and miR-429. RESULTS: Data found that MALAT1 was overexpressed in RCC clinical samples and cell lines. Moreover, loss-of-functional experiments showed that MALAT1 knockdown suppress the proliferation, migration, and invasion abilities of RCC cells. RT-PCR showed that miR-429 expression was downregulated in RCC cell lines, which was negatively correlated with that of MALAT1. Bioinformatics analysis suggested that miR-429 had complementary binding sequences with MALAT1, which was confirmed by dual-luciferase reporter assay. CONCLUSIONS: In summary, our results concluded that MALAT1 functioned as an oncogene in RCC by sponging miR-429, acting as its competing endogenous RNA (ceRNA). Twit Text FOAVip Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429 ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=29588438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29588438 #FOAvip English Wikipedia <ref>{{Cite pmid|29588438 }}</ref> Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429 #MMPMID29588438 Jiang LT ; Wan CH ; Guo QH ; Yang SJ ; Wu JD ; Cai J Med Sci Monit 2018[Mar]; 24 (ä): 1794-1801 PMID29588438 show ga BACKGROUND: It is well known that long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely correlated with the tumorigenesis of multiple cancers, including renal cell carcinoma (RCC). However, the potential functional mechanism is still elusive. MATERIAL/METHODS: In our present research, quantitative real-time polymerase chain reaction (qRT-PCR) was performed for the measurement of MALAT1 and miR-429. CCK-8 assay and Transwell assay were performed for the proliferation, migration, and invasion abilities of RCC cells. Dual-luciferase reporter assay was performed to validate the interaction within MALAT1 and miR-429. RESULTS: Data found that MALAT1 was overexpressed in RCC clinical samples and cell lines. Moreover, loss-of-functional experiments showed that MALAT1 knockdown suppress the proliferation, migration, and invasion abilities of RCC cells. RT-PCR showed that miR-429 expression was downregulated in RCC cell lines, which was negatively correlated with that of MALAT1. Bioinformatics analysis suggested that miR-429 had complementary binding sequences with MALAT1, which was confirmed by dual-luciferase reporter assay. CONCLUSIONS: In summary, our results concluded that MALAT1 functioned as an oncogene in RCC by sponging miR-429, acting as its competing endogenous RNA (ceRNA). |Adult [MESH] |Aged [MESH] |Carcinoma, Renal Cell/*genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |Cell Survival/genetics [MESH] |Disease Progression [MESH] |Female [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Kidney Neoplasms/*genetics/metabolism/pathology [MESH] |Male [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Middle Aged [MESH]Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcrip(epmc).pdf DeepDyve Pubget Overpricing