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2018 ; 11
(2
): 265-269
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Clinical course after parathyroidectomy in adults with end-stage renal disease on
maintenance dialysis
#MMPMID29644069
Lim CTS
; Kalaiselvam T
; Kitan N
; Goh BL
Clin Kidney J
2018[Apr]; 11
(2
): 265-269
PMID29644069
show ga
BACKGROUND: Parathyroidectomy (PTX) is done in cases of secondary
hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy.
Despite this widespread practice, clinical outcomes regarding the benefits of
this procedure are still lacking. Most studies in the literature have opted to
report the laboratory outcome instead. Our study aimed to evaluate the
postoperative clinical course for patients who had undergone total PTX without
autoimplantation. METHODS AND RESULTS: All patients who underwent PTX between
January 2010 and February 2014 in a tertiary referral center were included in
this study and followed up for 12?months. Laboratory outcome parameters include
various preoperative and postoperative serial measurements of laboratory
parameters. Patients' hospitalizations and mortality records post-PTX were also
retrieved and recorded. In all, 90 patients were included in this study. The mean
age was 48 ± 18?years. The majority of the patients (54.4%) were male and 90%
were on hemodialysis. The mean duration of dialysis was 8.0 ± 5.0?years.
Indications for PTX were symptomatic bone pain (95.6%), fractures (3.3%) and
calciphylaxis (1.1%). Mean preoperative values for serum calcium, phosphate,
alkaline phosphatase and intact parathyroid hormone (iPTH) were 2.40 ±
0.23mmol/L, 1.92 ± 0.51?mmol/L, 689.60 ± 708.50?U/L and 311.90 ± 171.94?pmol/L,
respectively. The majority (92.2%) had all four glands removed and 92.2% of the
glands showed hyperplasic changes. One year after PTX, 90 patients (100%) had
serum iPTH <8?pmol/L and 28 patients (31%) had unmeasurable iPTH levels. A total
of 15% of patients had hospitalizations for various reasons and of these, 50%
were within 90 days. The mean hospital stay was 14.4 ± 18.6 days. The mortality
rate was 4.4% and of these, 25% were in first 30 days. Causes of death were
mainly from sepsis (75%) and acute coronary syndrome (25%). One patient (1.1%)
had a relapse. CONCLUSIONS: Even though PTX markedly reduces postoperative serum
iPTH levels, it carries with it significant risk of morbidity and mortality.