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10.1093/rb/rby005

http://scihub22266oqcxt.onion/10.1093/rb/rby005
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suck abstract from ncbi


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pmid29644088
      Regen+Biomater 2018 ; 5 (2 ): 69-76
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  • Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogenin-derived peptide on initial caries lesions #MMPMID29644088
  • Ren Q ; Li Z ; Ding L ; Wang X ; Niu Y ; Qin X ; Zhou X ; Zhang L
  • Regen Biomater 2018[Mar]; 5 (2 ): 69-76 PMID29644088 show ga
  • In this study, we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel (CS-QP5 hydrogel), and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions. The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm, lactic acid production and the metabolic activity over a prolonged period of time. Moreover, the CS-QP5 hydrogel promoted the remineralization of early enamel lesions, which were indicated by surface micro-hardness (, polarized light microscopy and transverse microradiography. In conclusion, the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time.
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