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2018 ; 5
(2
): 69-76
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Anti-biofilm and remineralization effects of chitosan hydrogel containing
amelogenin-derived peptide on initial caries lesions
#MMPMID29644088
Ren Q
; Li Z
; Ding L
; Wang X
; Niu Y
; Qin X
; Zhou X
; Zhang L
Regen Biomater
2018[Mar]; 5
(2
): 69-76
PMID29644088
show ga
In this study, we have designed a more clinically powerful anti-caries treatment
by applying the amelogenin-derived peptide QP5 to the antibacterial carrier
material chitosan in a hydrogel (CS-QP5 hydrogel), and characterized its effects
on the inhibition of a cariogenic biofilm and the promotion of the
remineralization of the initial caries lesions. The results indicated that the
CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans
biofilm, lactic acid production and the metabolic activity over a prolonged
period of time. Moreover, the CS-QP5 hydrogel promoted the remineralization of
early enamel lesions, which were indicated by surface micro-hardness (, polarized
light microscopy and transverse microradiography. In conclusion, the CS-QP5
hydrogel shows good potential for caries control in the clinic because of its
antibacterial effects as well as the remineralization of initial enamel carious
lesions even in a biofilm model over a prolonged period of time.