Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29622010
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Orthop+Surg+Res
2018 ; 13
(1
): 72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Mechanical barriers and transforming growth factor beta inhibitor on epidural
fibrosis in a rabbit laminectomy model
#MMPMID29622010
Albiñana-Cunningham JN
; Ripalda-Cemboráin P
; Labiano T
; Echeveste JI
; Granero-Moltó F
; Alfonso-Olmos M
J Orthop Surg Res
2018[Apr]; 13
(1
): 72
PMID29622010
show ga
BACKGROUND: TGF-? has been described as a mediator of fibrosis and scarring.
Several studies achieved reduction in experimental scarring through the
inhibition of TGF-?. Fibroblasts have been defined as the cell population
originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis
appearance. For this purpose, biocompatible materials used as mechanical barriers
and a TGF-? inhibitor peptide were evaluated in the reduction of epidural
fibrosis. METHODS: A L6 laminectomy was performed in 40 New Zealand white
rabbits. Divided into four groups, each rabbit was assigned to receive either
collagen sponge scaffold (CS group), gelatin-based gel (GCP group), P144® (iTGF?
group), or left untreated (control group). Four weeks after surgery, cell
density, collagen content, and new bone formation of the scar area were
determined by histomorphometry. Two experienced pathologists scored dura mater
adhesion, scar density, and inflammatory infiltrate in a blinded manner. RESULTS:
In all groups, laminectomy site was filled with fibrous tissue and the dura mater
presented adhesions. Only GCP group presented a significant reduction in collagen
content and scar density. CONCLUSION: GCP treatment reduces epidural fibrosis
although did not prevent dura mater adhesion completely.
|Animals
[MESH]
|Biocompatible Materials
[MESH]
|Cicatrix/etiology/pathology/prevention & control
[MESH]
|Collagen/metabolism
[MESH]
|Disease Models, Animal
[MESH]
|Dura Mater/metabolism/pathology
[MESH]
|Epidural Space/metabolism/*pathology
[MESH]
|Fibrosis
[MESH]
|Laminectomy/*adverse effects
[MESH]
|Male
[MESH]
|Organic Chemicals/therapeutic use
[MESH]
|Peptide Fragments/*therapeutic use
[MESH]
|Rabbits
[MESH]
|Receptors, Transforming Growth Factor beta/*therapeutic use
[MESH]
|Tissue Adhesions/etiology/pathology/*prevention & control
[MESH]
free
free
free
