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10.1007/s13730-018-0308-3

http://scihub22266oqcxt.onion/10.1007/s13730-018-0308-3
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suck abstract from ncbi


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pmid29396817
      CEN+Case+Rep 2018 ; 7 (1 ): 121-126
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  • Renal medullary carcinoma: a nearly fatal malignancy specifically affecting patients with a so-called benign condition #MMPMID29396817
  • Goenaga-Vázquez Y ; Colón G ; Barrios N ; Correa M
  • CEN Case Rep 2018[May]; 7 (1 ): 121-126 PMID29396817 show ga
  • Renal medullary carcinoma (RMC) is a highly aggressive and rare malignancy found almost exclusively in young patients with sickle cell trait (SCT). Metastatic disease is commonly present at diagnosis. There is very limited experience treating disseminated disease and the prognosis is dismal. We report the case of a young 9-year-old boy with SCT, who presented with 4 months' progression of abdominal pain, nausea and vomiting associated with cough spells, dysphagia, and weight loss. Upon evaluation, he was underweight, pale, and in mild respiratory distress. Cervical lymphadenopathy was evident and abdomen was diffusely tender. A whole-body CT scan showed a left kidney lesion with associated cervical, mediastinal, and retroperitoneal lymphadenopathy. Biopsy of a cervical lymph node revealed metastatic RMC. Patient was started on combination chemotherapy with paclitaxel, carboplatin, and gemcitabine followed by left adrenalectomy. In spite of having advanced disease, our patient achieved an excellent response with a progression-free survival of 17 months. Although SCT is thought to be a "benign" condition, RMC is one devastating complication associated with it. Considering its rarity, the near uniform associated fatality should prompt the question of whether clinical practice should change regarding proper counseling of these patients and raise awareness in the medical community.
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