Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29349731
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 CEN+Case+Rep
2018 ; 7
(1
): 101-106
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Membranous nephropathy associated with pregnancy: an anti-phospholipase A2
receptor antibody-positive case report
#MMPMID29349731
Uchino E
; Takada D
; Mogami H
; Matsubara T
; Tsukamoto T
; Yanagita M
CEN Case Rep
2018[May]; 7
(1
): 101-106
PMID29349731
show ga
Pregnancy and membranous nephropathy (MN) can occur concurrently with nephrotic
syndrome. However, the pathophysiology of MN associated with pregnancy remains
unclear, including the involvement of anti-M-type phospholipase A2 receptor
(PLA2R) antibody, the major antigen of idiopathic MN (iMN). A treatment for the
condition is also not established. We present the case of a 43-year-old pregnant
female with incidental proteinuria and hypoalbuminemia. We made a diagnosis of
nephrotic syndrome at 11 week gestation. Renal biopsy revealed iMN using
predominant granular staining of IgG4 along the glomerular basement membrane. No
secondary cause was identified. Oral glucocorticoid therapy was started from 17
week gestation and induced complete remission at 28 week gestation. A healthy
infant was born at 38 week gestation. Glucocorticoid therapy was stopped
postpartum without MN relapse. Anti-PLA2R antibody was later found to be positive
using serum reserved from before treatment. In conclusion, we presented the case
of a pregnant woman with iMN and anti-PLA2R antibodies, whose nephrotic syndrome
was successfully controlled with oral glucocorticoids to reach complete
remission, even after tapering off the medication. Pregnancy per se might be
associated with iMN onset.