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A case of acute kidney injury caused by granulomatous interstitial nephritis
associated with sarcoidosis
#MMPMID29181823
Horino T
; Matsumoto T
; Inoue K
; Ichii O
; Terada Y
CEN Case Rep
2018[May]; 7
(1
): 34-38
PMID29181823
show ga
Sarcoidosis affects multiple organs including lung, heart and kidney. Sarcoidosis
causes hypercalcemia, hypergammaglobulinemia, and rarely, granulomatous
interstitial nephritis, resulting in renal stromal damage. Granulomatous
interstitial nephritis is characterized as interstitial nephritis with
noncaseating epithelioid granulomas. Diagnosing granulomatous interstitial
nephritis before patient's death is challenging; hence, only few cases proven by
renal biopsy have been reported till date. We present a case of acute kidney
injury caused by granulomatous interstitial nephritis as a renal manifestation of
sarcoidosis proven by renal biopsy, which can be confirmed by
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography.
Glucocorticoid therapy was helpful for improving and maintaining her renal
function over a 6-year period.