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2018 ; 7
(1
): 24-28
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Maintenance treatment using the purine-synthesis inhibitor mizoribine in a
patient with relapsing thrombotic thrombocytopenic purpura
#MMPMID29124560
Kawamura T
; Usui J
; Nagai K
; Sakai K
; Ebihara I
; Yamagata K
CEN Case Rep
2018[May]; 7
(1
): 24-28
PMID29124560
show ga
Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening disease.
Although plasma exchange (PE) therapy and corticosteroids are standard remission
induction and maintenance therapies, some patients are easily refractory and
frequently relapse under treatment with this therapy, and require additional
treatment. However, there are limited data about additional treatment
interventions. We report a case of 56-year-old man who was hospitalized for
fever, general fatigue and hemoglobinuria. Owing to the symptoms and the
laboratory findings of hemolysis, he was diagnosed with TTP. He was treated with
PE therapy and corticosteroids, and the TTP went into remission. However, his TTP
relapsed and remission induction was attempted again. As a remission maintenance
treatment, we used combination therapy with the purine-synthesis inhibitor
mizoribine (MZR) and corticosteroids. The administration of MZR maintained
disease activity with no adverse event for long periods and allowed us to
gradually reduce the corticosteroids dose. Hence, we propose that MZR is an
effective treatment for TTP maintenance.