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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Drug+Metab 2018 ; 19 (1): 3-46 Nephropedia Template TP
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Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo a pyrene #MMPMID29219051
Rendic SP; Guengerich FP
Curr Drug Metab 2018[]; 19 (1): 3-46 PMID29219051show ga
The present work describes development and use of offline and Web-searchable human and other species metabolism databases. A search of the databases presented will produce basic information on metabolic reactions or transporter systems published on specific drug or other chemical, kinetic values, as well as structure of the metabolites. In addition, searching enables comparison of the data between different species models. The data cover time the period until 2008, and the current Web-searchable database [19] is updated quarterly each year and over the period until October 2017. Users of the databases might find occasional discrepancies between the data searched, e.g. data on metabolic activations as presented in Table 6. This is because the data were collected from different literature sources over the time of collection. The data searched may find their application in prediction and interpretation of the metabolism of drugs and other chemicals, drug design, and development, as well as in clinical and toxicological studies. Application of data searching to the study of xeno- or endobiotics metabolism is illustrated by those searched for the properties of the known environmental carcinogens benzo[a]pyrene (B[a]P) and its metabolites covering the period until the year 2008. The results of the data analysis show higher activity of P450 1A1 for metabolic activation of the (?)- isomer, while P4501B1 exerts higher activity for the (+)- isomer of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene (trans-B[a]P-7,8-diol). P450 1A2 showed equally low activity in the metabolic activation of both isomers (Tables 2 and 3). The current Web-searchable metabolism database contains 125,359 entries.