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10.1371/journal.ppat.1006955 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006955 C5886688!5886688 !29621339     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29621339 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia |pdf=|usr=}}{{29621339 }} gab.com Text Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29621339 #FOAvip Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice. Notably, CAM pretreatment enhanced survival in a mouse model of lipopolysaccharide (LPS)-induced shock. In addition, adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice against LPS-induced lethality via increased IL-10 expression. CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-? and increased IL-10 levels. Adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice from post-influenza pneumococcal pneumonia. Further analysis revealed that the CAM-induced CD11b+Gr-1+ cell expansion was dependent on STAT3-mediated Bv8 production and may be facilitated by the presence of gut commensal microbiota. Lastly, an analysis of peripheral blood obtained from healthy volunteers following oral CAM administration showed a trend toward the expansion of human MDSC-like cells (Lineage-HLA-DR-CD11b+CD33+) with increased arginase 1 mRNA expression. Thus, CAM promoted the expansion of a unique population of immunosuppressive CD11b+Gr-1+ cells essential for the immunomodulatory properties of macrolides. Twit Text FOAVip Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29621339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29621339 #FOAvip English Wikipedia <ref>{{Cite pmid|29621339 }}</ref> Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia #MMPMID29621339 Namkoong H ; Ishii M ; Fujii H ; Yagi K ; Asami T ; Asakura T ; Suzuki S ; Hegab AE ; Kamata H ; Tasaka S ; Atarashi K ; Nakamoto N ; Iwata S ; Honda K ; Kanai T ; Hasegawa N ; Koyasu S ; Betsuyaku T PLoS Pathog 2018[Apr]; 14 (4 ): e1006955 PMID29621339 show ga Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice. Notably, CAM pretreatment enhanced survival in a mouse model of lipopolysaccharide (LPS)-induced shock. In addition, adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice against LPS-induced lethality via increased IL-10 expression. CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-? and increased IL-10 levels. Adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice from post-influenza pneumococcal pneumonia. Further analysis revealed that the CAM-induced CD11b+Gr-1+ cell expansion was dependent on STAT3-mediated Bv8 production and may be facilitated by the presence of gut commensal microbiota. Lastly, an analysis of peripheral blood obtained from healthy volunteers following oral CAM administration showed a trend toward the expansion of human MDSC-like cells (Lineage-HLA-DR-CD11b+CD33+) with increased arginase 1 mRNA expression. Thus, CAM promoted the expansion of a unique population of immunosuppressive CD11b+Gr-1+ cells essential for the immunomodulatory properties of macrolides. |Animals [MESH] |Anti-Bacterial Agents/pharmacology [MESH] |CD11b Antigen/genetics/metabolism [MESH] |Cell Differentiation/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Clarithromycin/*pharmacology [MESH] |Gastrointestinal Hormones/genetics/*metabolism [MESH] |Lipopolysaccharides/toxicity [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myeloid Cells/cytology/drug effects/microbiology/virology [MESH] |Neuropeptides/genetics/*metabolism [MESH] |Orthomyxoviridae Infections/*complications/virology [MESH] |Orthomyxoviridae/pathogenicity [MESH] |Phagocytosis/drug effects [MESH] |Pneumonia, Pneumococcal/*drug therapy/microbiology/virology [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Shock, Septic/chemically induced/*drug therapy [MESH]Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ame(epmc).pdf DeepDyve Pubget Overpricing