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10.1093/hmg/ddx240 http://scihub22266oqcxt.onion/10.1093/hmg/ddx240 C5886477!5886477!28977444     free     free     free       Hum+Mol+Genet 2017 ; 26 (R2): R128-38 Nephropedia Template TP {{tp|p=28977444|t=2017. The genetics of circadian rhythms, sleep and health |pdf=|usr=}}{{28977444}} gab.com Text The genetics of circadian rhythms, sleep and health JO: Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=28977444 #FOAvip Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today?s 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3?5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health. Twit Text FOAVip The genetics of circadian rhythms, sleep and health ????Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=28977444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28977444 #FOAvip English Wikipedia <ref>{{Cite pmid|28977444}}</ref> The genetics of circadian rhythms, sleep and health #MMPMID28977444 Jagannath A; Taylor L; Wakaf Z; Vasudevan SR; Foster RG Hum Mol Genet 2017[Oct]; 26 (R2): R128-38 PMID28977444show ga Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today?s 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3?5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health. äThe genetics of circadian rhythms, sleep and health (epmc).pdf DeepDyve Pubget Overpricing