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2017 ; 58
(1
): 17-41
Nephropedia Template TP
gab.com Text
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English Wikipedia
Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological
Knowledgebase for the Laboratory Mouse
#MMPMID28838066
Eppig JT
ILAR J
2017[Jul]; 58
(1
): 17-41
PMID28838066
show ga
The Mouse Genome Informatics (MGI) Resource supports basic, translational, and
computational research by providing high-quality, integrated data on the
genetics, genomics, and biology of the laboratory mouse. MGI serves a strategic
role for the scientific community in facilitating biomedical, experimental, and
computational studies investigating the genetics and processes of diseases and
enabling the development and testing of new disease models and therapeutic
interventions. This review describes the nexus of the body of growing genetic and
biological data and the advances in computer technology in the late 1980s,
including the World Wide Web, that together launched the beginnings of MGI. MGI
develops and maintains a gold-standard resource that reflects the current state
of knowledge, provides semantic and contextual data integration that fosters
hypothesis testing, continually develops new and improved tools for searching and
analysis, and partners with the scientific community to assure research data
needs are met. Here we describe one slice of MGI relating to the development of
community-wide large-scale mutagenesis and phenotyping projects and introduce
ways to access and use these MGI data. References and links to additional MGI
aspects are provided.