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2018 ; 2018
(ä): 8192021
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Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic
Antibody-Associated Vasculitis
#MMPMID29765786
Ishii Y
; Shirai T
; Hoshi Y
; Fujita Y
; Shirota Y
; Fujii H
; Ishii T
; Harigae H
Case Rep Rheumatol
2018[]; 2018
(ä): 8192021
PMID29765786
show ga
Here, we present the case of a 29-year-old woman with nasal septal perforation
and positive myeloperoxidase- (MPO-) anti-neutrophil cytoplasmic antibody (ANCA).
She had been diagnosed with Graves' disease and had been treated with
propylthiouracil (PTU) for 14 months. A biopsy of the nasal septum revealed an
infiltration of inflammatory cells, with no evidence of malignancy or
granulomatous change. Because of the use of PTU, destructive nasal lesion, and
positive MPO-ANCA, she was diagnosed with drug-induced ANCA-associated vasculitis
(AAV) and was treated with prednisolone and methotrexate after the cessation of
PTU. Although PTU is known to be the medicine that induces drug-induced AAV, the
manifestation of nasal septal perforation in drug-induced AAV is poorly
identified. This is the rare case of drug-induced AAV which manifested only nasal
septal perforation.