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10.1186/s12885-018-4315-8 http://scihub22266oqcxt.onion/10.1186/s12885-018-4315-8 C5885370!5885370!29618339     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Cancer 2018 ; 18 (ä): ä Nephropedia Template TP {{tp|p=29618339|t=2018. Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma |pdf=|usr=}}{{29618339}} gab.com Text Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29618339 #FOAvip Background: Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in the degradation of the extracellular matrix. Involvement in pathological processes, such as inflammation and cancer progression, has been proved. The aim of the study was to discover the clinicopathological and prognostic implications of cathepsin K (CTSK) expression in oral squamous cell carcinoma. Methods: Eighty-three patients with primary OSCC, treated surgically between 1996 and 2000, were included. Gene expression data were acquired from a previously reported study. Human papilloma virus (HPV) status was previously determined by an algorithm for HPV-16. CTSK Protein expression was semi-quantitatively determined by immunohistochemistry in tumor and stromal cells. Expression data were correlated with various clinicopathological variables. Results: Elevated gene and protein expression of CTSK were strongly associated to LNM and perineural invasion (p?<?0.01). Logistic regression analysis highlighted increased CTSK protein expression in tumor cells as the most significant independent factor of lymphatic metastasis (OR?=?7.65, CI:2.31?23.31, p?=?0.001). Survival analysis demonstrated CTSK protein expression in both stromal and tumor cells as significant indicators of poor 5-year disease specific survival (HR?=?2.40, CI:1.05?5.50, p?=?0.038 for stromal cells; HR?=?2.79, CI:1.02?7.64, p?=?0.045 for tumor cells). Conclusion: Upregulation of CTSK seems to be associated with high incidence of lymphatic spread and poor survival in OSCC. CTSK could therefore serve as a predictive biomarker for OSCC. Electronic supplementary material: The online version of this article (10.1186/s12885-018-4315-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29618339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29618339 #FOAvip English Wikipedia <ref>{{Cite pmid|29618339}}</ref> Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma #MMPMID29618339 Leusink FK; Koudounarakis E; Frank MH; Koole R; van Diest PJ; Willems SM BMC Cancer 2018[]; 18 (ä): ä PMID29618339show ga Background: Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in the degradation of the extracellular matrix. Involvement in pathological processes, such as inflammation and cancer progression, has been proved. The aim of the study was to discover the clinicopathological and prognostic implications of cathepsin K (CTSK) expression in oral squamous cell carcinoma. Methods: Eighty-three patients with primary OSCC, treated surgically between 1996 and 2000, were included. Gene expression data were acquired from a previously reported study. Human papilloma virus (HPV) status was previously determined by an algorithm for HPV-16. CTSK Protein expression was semi-quantitatively determined by immunohistochemistry in tumor and stromal cells. Expression data were correlated with various clinicopathological variables. Results: Elevated gene and protein expression of CTSK were strongly associated to LNM and perineural invasion (p? äCathepsin K associates with lymph node metastasis and poor prognosis i(epmc).pdf DeepDyve Pubget Overpricing