Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncb3284 http://scihub22266oqcxt.onion/10.1038/ncb3284 C5885286!5885286!26641718     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2016 ; 18 (1): 43-53 Nephropedia Template TP {{tp|p=26641718|t=2016. Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells |pdf=|usr=}}{{26641718}} gab.com Text Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26641718 #FOAvip Dendritic cell (DC) migration in peripheral tissues serves two main functions: antigen sampling by immature DCs, and chemokine-guided migration towards lymphatic vessels (LVs) on maturation. These migratory events determine the efficiency of the adaptive immune response. Their regulation by the core cell locomotion machinery has not been determined. Here, we show that the migration of immature DCs depends on two main actin pools: a RhoA?mDia1-dependent actin pool located at their rear, which facilitates forward locomotion; and a Cdc42?Arp2/3-dependent actin pool present at their front, which limits migration but promotes antigen capture. Following TLR4?MyD88-induced maturation, Arp2/3-dependent actin enrichment at the cell front is markedly reduced. Consequently, mature DCs switch to a faster and more persistent mDia1-dependent locomotion mode that facilitates chemotactic migration to LVs and lymph nodes. Thus, the differential use of actin-nucleating machineries optimizes the migration of immature and mature DCs according to their specific function. Twit Text FOAVip Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26641718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26641718 #FOAvip English Wikipedia <ref>{{Cite pmid|26641718}}</ref> Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells #MMPMID26641718 Vargas P; Maiuri P; Bretou M; Sáez PJ; Pierobon P; Maurin M; Chabaud M; Lankar D; Obino D; Terriac E; Raab M; Thiam HR; Brocker T; Kitchen-Goosen SM; Alberts AS; Sunareni P; Xia S; Li R; Voituriez R; Piel M; Lennon-Duménil AM Nat Cell Biol 2016[Jan]; 18 (1): 43-53 PMID26641718show ga Dendritic cell (DC) migration in peripheral tissues serves two main functions: antigen sampling by immature DCs, and chemokine-guided migration towards lymphatic vessels (LVs) on maturation. These migratory events determine the efficiency of the adaptive immune response. Their regulation by the core cell locomotion machinery has not been determined. Here, we show that the migration of immature DCs depends on two main actin pools: a RhoA?mDia1-dependent actin pool located at their rear, which facilitates forward locomotion; and a Cdc42?Arp2/3-dependent actin pool present at their front, which limits migration but promotes antigen capture. Following TLR4?MyD88-induced maturation, Arp2/3-dependent actin enrichment at the cell front is markedly reduced. Consequently, mature DCs switch to a faster and more persistent mDia1-dependent locomotion mode that facilitates chemotactic migration to LVs and lymph nodes. Thus, the differential use of actin-nucleating machineries optimizes the migration of immature and mature DCs according to their specific function. äInnate control of actin nucleation determines two distinct migration b(epmc).pdf DeepDyve Pubget Overpricing