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10.1038/nature24302 http://scihub22266oqcxt.onion/10.1038/nature24302 C5884449!5884449!29144460     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 551 (7680): 340-5 Nephropedia Template TP {{tp|p=29144460|t=2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity |pdf=|usr=}}{{29144460}} gab.com Text Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=29144460 #FOAvip The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens. Whereas CD8+ T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA+ cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8+ T-lymphocyte activation as a tumour-promoting mechanism. Twit Text FOAVip Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=29144460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29144460 #FOAvip English Wikipedia <ref>{{Cite pmid|29144460}}</ref> Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity #MMPMID29144460 Shalapour S; Lin XJ; Bastian IN; Brain J; Burt AD; Aksenov AA; Vrbanac AF; Li W; Perkins A; Matsutani T; Zhong Z; Dhar D; Navas-Molina JA; Xu J; Loomba R; Downes M; Yu RT; Evans RM; Dorrestein PC; Knight R; Benner C; Anstee QM; Karin M Nature 2017[Nov]; 551 (7680): 340-5 PMID29144460show ga The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens. Whereas CD8+ T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA+ cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8+ T-lymphocyte activation as a tumour-promoting mechanism. äInflammation-induced IgA+ cells dismantle anti-liver cancer immunity (epmc).pdf DeepDyve Pubget Overpricing