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10.1155/2018/6730315 http://scihub22266oqcxt.onion/10.1155/2018/6730315 C5884145!5884145 !29744366     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29744366 &cmd=llinks): Failed to open stream: HTTP request failed! 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Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats |pdf=|usr=}}{{29744366 }} gab.com Text Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats JO: J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29744366 #FOAvip Astaxanthin (AST), a natural keto-carotenoid classified as a xanthophyll, is well known for its antioxidant properties. AST can ameliorate the pathological characteristics of diabetic nephropathy (DN). However, the underlying mechanisms remain to be explored. This study was aimed at exploring whether AST exerts a protective effect on DN via activating nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidative response element (ARE) signaling. Streptozotocin-induced diabetic rats were treated with AST for 12 weeks. We found that AST treatment ameliorated renal morphological injury. Reduced fibronectin and collagen IV protein expression were found in the kidneys of diabetic rats. Furthermore, AST promoted the nuclear translocation of Nrf2 and increased its downstream protein heme oxygenase-1 and superoxide dismutase 1 expression. AST also increased the activity of SOD and decreased malondialdehyde generation in the serum of diabetic rats. These results suggest that the renoprotective effect of AST on DN partly depends on Nrf2-ARE signaling. The antioxidative stress effect of AST is responsible for the activation of Nrf2-ARE signaling in DN. Twit Text FOAVip Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats ????J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29744366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29744366 #FOAvip English Wikipedia <ref>{{Cite pmid|29744366 }}</ref> Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats #MMPMID29744366 Zhu X ; Chen Y ; Chen Q ; Yang H ; Xie X J Diabetes Res 2018[]; 2018 (ä): 6730315 PMID29744366 show ga Astaxanthin (AST), a natural keto-carotenoid classified as a xanthophyll, is well known for its antioxidant properties. AST can ameliorate the pathological characteristics of diabetic nephropathy (DN). However, the underlying mechanisms remain to be explored. This study was aimed at exploring whether AST exerts a protective effect on DN via activating nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidative response element (ARE) signaling. Streptozotocin-induced diabetic rats were treated with AST for 12 weeks. We found that AST treatment ameliorated renal morphological injury. Reduced fibronectin and collagen IV protein expression were found in the kidneys of diabetic rats. Furthermore, AST promoted the nuclear translocation of Nrf2 and increased its downstream protein heme oxygenase-1 and superoxide dismutase 1 expression. AST also increased the activity of SOD and decreased malondialdehyde generation in the serum of diabetic rats. These results suggest that the renoprotective effect of AST on DN partly depends on Nrf2-ARE signaling. The antioxidative stress effect of AST is responsible for the activation of Nrf2-ARE signaling in DN. |Animals [MESH] |Antioxidant Response Elements/physiology [MESH] |Antioxidants/*pharmacology/therapeutic use [MESH] |Collagen Type IV/*metabolism [MESH] |Diabetes Mellitus, Experimental/drug therapy/metabolism [MESH] |Diabetic Nephropathies/*drug therapy/metabolism [MESH] |Fibronectins/*metabolism [MESH] |Heme Oxygenase-1/metabolism [MESH] |Kidney/*drug effects/metabolism [MESH] |Male [MESH] |NF-E2-Related Factor 2/metabolism [MESH] |Oxidative Stress/drug effects [MESH] |Rats [MESH] |Reactive Oxygen Species/metabolism [MESH] |Signal Transduction/*drug effects [MESH] |Superoxide Dismutase-1/metabolism [MESH]Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin(epmc).pdf DeepDyve Pubget Overpricing