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10.1016/j.neo.2018.01.005 http://scihub22266oqcxt.onion/10.1016/j.neo.2018.01.005 C5883632!5883632!29476980     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neoplasia 2018 ; 20 (3): 295-303 Nephropedia Template TP {{tp|p=29476980|t=2018. Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation |pdf=|usr=}}{{29476980}} gab.com Text Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation JO: Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=29476980 #FOAvip It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to undergo apoptosis could recover with increased tumorigenicity in vitro and in vivo, and induced lymph node metastasis. Specifically, the reversed cells underwent epithelial-to-mesenchymal transitions in the primary tumors in situ, and mesenchymal-to-epithelial transitions in the metastatic cells. Flow cytometry confirmed an elevated percentage of cells carrying cancer stem cells (CSCs) markers (CD44+/CD24-) in the reversed breast cancer cell population, with hypomethylated CD44 promoters and hypermethylated CD24 promoters. More importantly, CSCs were generated anew from non-stem cancer cells after apoptosis reversal possibly through epigenetic modifications. The results from this study can open doors to discovering more effective cancer treatments by suppressing apoptosis reversal. Twit Text FOAVip Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation ????Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=29476980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29476980 #FOAvip English Wikipedia <ref>{{Cite pmid|29476980}}</ref> Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation #MMPMID29476980 Xu Y; So C; Lam HM; Fung MC; Tsang SY Neoplasia 2018[Mar]; 20 (3): 295-303 PMID29476980show ga It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to undergo apoptosis could recover with increased tumorigenicity in vitro and in vivo, and induced lymph node metastasis. Specifically, the reversed cells underwent epithelial-to-mesenchymal transitions in the primary tumors in situ, and mesenchymal-to-epithelial transitions in the metastatic cells. Flow cytometry confirmed an elevated percentage of cells carrying cancer stem cells (CSCs) markers (CD44+/CD24-) in the reversed breast cancer cell population, with hypomethylated CD44 promoters and hypermethylated CD24 promoters. More importantly, CSCs were generated anew from non-stem cancer cells after apoptosis reversal possibly through epigenetic modifications. The results from this study can open doors to discovering more effective cancer treatments by suppressing apoptosis reversal. äApoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation (epmc).pdf DeepDyve Pubget Overpricing