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10.1186/s12916-018-1038-2 http://scihub22266oqcxt.onion/10.1186/s12916-018-1038-2 C5883397!5883397!29615035     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29615035&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2018 ; 16 (ä): ä Nephropedia Template TP {{tp|p=29615035|t=2018. Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?|pdf=|usr=}}{{29615035}} gab.com Text Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=29615035 #FOAvip Introduction: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This debate article seeks to evaluate and provide recommendation on how to characterize pragmatic RCTs in light of the current landscape of RCTs. It is supported by findings from a PubMed search conducted in August 2017, which retrieved 615 RCTs self-labeled in their titles as ?pragmatic? or ?naturalistic?. We focused on 89 of these trials that assessed medicines (drugs or biologics). Discussion: 36% of these 89 trials were placebo-controlled, performed before licensing of the medicine, or done in a single-center. In our opinion, such RCTs overtly deviate from usual care and pragmatism. It follows, that the use of the term ?pragmatic? to describe them, conveys a misleading message to patients and clinicians. Furthermore, many other trials among the 615 coined as ?pragmatic? and assessing other types of intervention are plausibly not very pragmatic; however, this is impossible for a reader to tell without access to the full protocol and insider knowledge of the trial conduct. The degree of pragmatism should be evaluated by the trial investigators themselves using the PRECIS-2 tool, a tool that comprises 9 domains, each scored from 1 (very explanatory) to 5 (very pragmatic). Conclusions: To allow for a more appropriate characterization of the degree of pragmatism in clinical research, submissions of RCTs to funders, research ethics committees and to peer-reviewed journals should include a PRECIS-2 tool assessment done by the trial investigators. Clarity and accuracy on the extent to which a RCT is pragmatic will help understand how much it is relevant to real-world practice. Twit Text FOAVip Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=29615035 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615035 #FOAvip English Wikipedia <ref>{{Cite pmid|29615035}}</ref> Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? #MMPMID29615035 Dal-Ré R; Janiaud P; Ioannidis JPA BMC Med 2018[]; 16 (ä): ä PMID29615035show ga Introduction: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This debate article seeks to evaluate and provide recommendation on how to characterize pragmatic RCTs in light of the current landscape of RCTs. It is supported by findings from a PubMed search conducted in August 2017, which retrieved 615 RCTs self-labeled in their titles as ?pragmatic? or ?naturalistic?. We focused on 89 of these trials that assessed medicines (drugs or biologics). Discussion: 36% of these 89 trials were placebo-controlled, performed before licensing of the medicine, or done in a single-center. In our opinion, such RCTs overtly deviate from usual care and pragmatism. It follows, that the use of the term ?pragmatic? to describe them, conveys a misleading message to patients and clinicians. Furthermore, many other trials among the 615 coined as ?pragmatic? and assessing other types of intervention are plausibly not very pragmatic; however, this is impossible for a reader to tell without access to the full protocol and insider knowledge of the trial conduct. The degree of pragmatism should be evaluated by the trial investigators themselves using the PRECIS-2 tool, a tool that comprises 9 domains, each scored from 1 (very explanatory) to 5 (very pragmatic). Conclusions: To allow for a more appropriate characterization of the degree of pragmatism in clinical research, submissions of RCTs to funders, research ethics committees and to peer-reviewed journals should include a PRECIS-2 tool assessment done by the trial investigators. Clarity and accuracy on the extent to which a RCT is pragmatic will help understand how much it is relevant to real-world practice. äReal-world evidence: How pragmatic are randomized controlled trials la(epmc).pdf DeepDyve Pubget Overpricing