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10.1016/j.yexcr.2018.02.015 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2018.02.015 C5883325!5883325 !29458174     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29458174 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Cell+Res 2018 ; 364 (2 ): 234-242 Nephropedia Template TP {{tp|p=29458174 |t=2018. Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes |pdf=|usr=}}{{29458174 }} gab.com Text Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=29458174 #FOAvip Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the elements that maintain nephrocyte architecture and the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of F-actin, which is maintained by the microtubule cytoskeleton and Rho-GTPases. A balance of Rac1 and Cdc42 activity as well as proper microtubule organization and endoplasmic reticulum structure, are required to position the actin cluster. Further, ND proteins Sns and Duf also localize to this cluster and regulate organization of the actin and microtubule cytoskeleton. Perturbation of any of these inter-dependent components impairs nephrocyte ultrafiltration. Thus cytoskeletal components, Rho-GTPases and ND proteins work in concert to maintain the specialized nephrocyte architecture and function. Twit Text FOAVip Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=29458174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29458174 #FOAvip English Wikipedia <ref>{{Cite pmid|29458174 }}</ref> Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes #MMPMID29458174 Muraleedharan S ; Sam A ; Skaer H ; Inamdar MS Exp Cell Res 2018[Mar]; 364 (2 ): 234-242 PMID29458174 show ga Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the elements that maintain nephrocyte architecture and the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of F-actin, which is maintained by the microtubule cytoskeleton and Rho-GTPases. A balance of Rac1 and Cdc42 activity as well as proper microtubule organization and endoplasmic reticulum structure, are required to position the actin cluster. Further, ND proteins Sns and Duf also localize to this cluster and regulate organization of the actin and microtubule cytoskeleton. Perturbation of any of these inter-dependent components impairs nephrocyte ultrafiltration. Thus cytoskeletal components, Rho-GTPases and ND proteins work in concert to maintain the specialized nephrocyte architecture and function. |Animals [MESH] |Cytoskeleton/drug effects/*metabolism [MESH] |Drosophila Proteins/*metabolism [MESH] |Drosophila/*cytology/*metabolism [MESH] |Endoplasmic Reticulum/drug effects/metabolism [MESH] |Kidney/*cytology/drug effects/*metabolism [MESH] |Metabolic Networks and Pathways/drug effects [MESH] |Nocodazole/pharmacology [MESH]Networks that link cytoskeletal regulators and diaphragm proteins unde(epmc).pdf DeepDyve Pubget Overpricing