15d-PGJ2 is a new hope for controlling tumor growth #MMPMID29636856
Bie Q; Dong H; Jin C; Zhang H; Zhang B
Am J Transl Res 2018[]; 10 (3): 648-58 PMID29636856show ga
15-deoxy-?12,14-prostaglandin J2 (15d-PGJ2), a natural PPAR? agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.