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2018 ; 8
(1
): 5422
Nephropedia Template TP
Wang J
; Yang W
; Wang T
; Chen X
; Wang J
; Zhang X
; Cai C
; Zhong B
; Wu J
; Chen Z
; Xiang AP
; Huang W
Sci Rep
2018[Apr]; 8
(1
): 5422
PMID29615660
show ga
Mesenchymal stromal cells (MSCs) have been considered as one of the pivotal type
of cells composing the tumor microenvironment. Although contact-dependent
mechanisms and paracrine factors are thought to collaborate in governing the
MSCs-based effects on tumors progression, the underlying mechanisms remain
largely unknown. In particular, the involvement of MSCs-derived cytokines in the
epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinoma
(ESCC) has not been clarified. In this study, we observed that ?2-Microglobulin
(B2M) is highly expressed in MSCs but scarcely in ESCC cells. Based on the
previously described EMT promoting effect of B2M, we investigated the in vitro
effect of MSCs-derived B2M on the EMT of ESCC cells, and discovered its
subsequent enhancing effects on cell mobility and tumor-initiation. Further
xenograft transplantation experiments confirmed the in vivo induction of
tumor-initiation by MSCs-derived B2M. Noteworthy, we showed that the B2M
expression positively correlated with poor prognosis. The fact that B2M is
primarily expressed by the stroma of the ESCC tissue strengthens our hypothesis
that in ESCC, MSCs-derived B2M promotes tumor-initiation and invasion via
enhancing EMT, resulting in an adverse prognosis for the patients. Our results
will be valuable for the prediction of the development and treatment of ESCC.
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