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10.1038/s41467-018-03651-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-03651-9 C5882805!5882805!29615609     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29615609|t=2018. Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid |pdf=|usr=}}{{29615609}} gab.com Text Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29615609 #FOAvip Peptide mediated gain-of-toxic function is central to pathology in Alzheimer?s, Parkinson?s and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and the relationship of structure to cytotoxicity is unaddressed. Here we focus on islet amyloid polypeptide (IAPP) mediated loss-of-insulin secreting cells in patients with diabetes. Newly developed methods enable structure-function enquiry to focus on intracellular oligomers composed of hundreds of IAPP. The key insights are that porating oligomers are internally dynamic, grow in discrete steps and are not canonical amyloid. Moreover, two classes of poration occur; an IAPP-specific ligand establishes that only one is cytotoxic. Toxic rescue occurs by stabilising non-toxic poration without displacing IAPP from mitochondria. These insights illuminate cytotoxic mechanism in diabetes and also provide a generalisable approach for enquiry applicable to other partially ordered protein assemblies. Twit Text FOAVip Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29615609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615609 #FOAvip English Wikipedia <ref>{{Cite pmid|29615609}}</ref> Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid #MMPMID29615609 Birol M; Kumar S; Rhoades E; Miranker AD Nat Commun 2018[]; 9 (ä): ä PMID29615609show ga Peptide mediated gain-of-toxic function is central to pathology in Alzheimer?s, Parkinson?s and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and the relationship of structure to cytotoxicity is unaddressed. Here we focus on islet amyloid polypeptide (IAPP) mediated loss-of-insulin secreting cells in patients with diabetes. Newly developed methods enable structure-function enquiry to focus on intracellular oligomers composed of hundreds of IAPP. The key insights are that porating oligomers are internally dynamic, grow in discrete steps and are not canonical amyloid. Moreover, two classes of poration occur; an IAPP-specific ligand establishes that only one is cytotoxic. Toxic rescue occurs by stabilising non-toxic poration without displacing IAPP from mitochondria. These insights illuminate cytotoxic mechanism in diabetes and also provide a generalisable approach for enquiry applicable to other partially ordered protein assemblies. äConformational switching within dynamic oligomers underpins toxic gain(epmc).pdf DeepDyve Pubget Overpricing