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10.1038/onc.2017.248 http://scihub22266oqcxt.onion/10.1038/onc.2017.248 C5882487!5882487!28783169     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2017 ; 36 (47): 6568-80 Nephropedia Template TP {{tp|p=28783169|t=2017. Glioblastoma stem cells exploit the ?v?8 integrin-TGF?1 signaling axis to drive tumor initiation and progression |pdf=|usr=}}{{28783169}} gab.com Text Glioblastoma stem cells exploit the v 8 integrin-TGF 1 signaling axis to drive tumor initiation and progression JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28783169 #FOAvip Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin ?v?8 and its latent transforming growth factor ?1 (TGF?1) protein ligand have central roles in promoting niche co-option and GBM initiation. ?v?8 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro. Fractionation of ?8high cells from freshly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo. Whole-transcriptome sequencing reveals that ?v?8 integrin regulates tumor development, in part, by driving TGF?1-induced DNA replication and mitotic checkpoint progression. Collectively, these data identify the ?v?8 integrin-TGF?1 signaling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic targets for inhibiting tumor growth and progression in patients with GBM. Twit Text FOAVip Glioblastoma stem cells exploit the v 8 integrin-TGF 1 signaling axis to drive tumor initiation and progression ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28783169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28783169 #FOAvip English Wikipedia <ref>{{Cite pmid|28783169}}</ref> Glioblastoma stem cells exploit the ?v?8 integrin-TGF?1 signaling axis to drive tumor initiation and progression #MMPMID28783169 Guerrero P; Tchaicha J; Chen Z; Morales J; McCarty N; Wang Q; Sulman E; Fuller G; Lang F; Rao G; McCarty J Oncogene 2017[Nov]; 36 (47): 6568-80 PMID28783169show ga Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin ?v?8 and its latent transforming growth factor ?1 (TGF?1) protein ligand have central roles in promoting niche co-option and GBM initiation. ?v?8 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro. Fractionation of ?8high cells from freshly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo. Whole-transcriptome sequencing reveals that ?v?8 integrin regulates tumor development, in part, by driving TGF?1-induced DNA replication and mitotic checkpoint progression. Collectively, these data identify the ?v?8 integrin-TGF?1 signaling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic targets for inhibiting tumor growth and progression in patients with GBM. äGlioblastoma stem cells exploit the ?v?8 integrin-TGF?1 signaling axis(epmc).pdf DeepDyve Pubget Overpricing