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10.1097/MD.0000000000010079

http://scihub22266oqcxt.onion/10.1097/MD.0000000000010079
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C5882404!5882404 !29538200
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suck abstract from ncbi


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pmid29538200
      Medicine+(Baltimore) 2018 ; 97 (11 ): e0079
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  • Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature #MMPMID29538200
  • Gao M ; Zhang W ; Zhao W ; Qin L ; Pei F ; Zheng Y
  • Medicine (Baltimore) 2018[Mar]; 97 (11 ): e0079 PMID29538200 show ga
  • RATIONALE: Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as "Loeffler endocarditis." PATIENT CONCERNS: We report a case of a 60-year-old man diagnosed with left-sided restrictive cardiomyopathy. DIAGNOSIS: The patient experienced heart failure with preserved ejection fraction. The cardiac MRI showed intense, linear, delayed gadolinium enhancement of the endocardium of the lateral wall of the left ventricle, and obliteration of the LV apex. He was ultimately identified as Loeffler endocarditis. INTERVENTION: A bone marrow smear and biopsy revealed the FIP1L1-PDGFRA fusion gene was positive in 82% of segmented nucleated cells. OUTCOME: Our patient responded well to prednisone at 1?mg/kg/d. LESSONS: HES is a rare disease that often afflicts the heart. Cardiac involvement in hypereosinophilia, especially Loeffler endocarditis, carries a poor prognosis and significant mortality. Early detection and treatment of the disease is therefore essential. Further studies are needed to ascertain therapeutic corticosteroid dosages and develop targeted gene therapies, both important steps to ameliorate the effects of Loeffler endocarditis and improve patient outcomes.
  • |*Cardiomyopathy, Restrictive/diagnosis/etiology [MESH]
  • |*Heart Failure/diagnosis/etiology [MESH]
  • |*Heart Ventricles/diagnostic imaging/physiopathology [MESH]
  • |*Hypereosinophilic Syndrome/diagnosis/drug therapy/physiopathology [MESH]
  • |*Oncogene Proteins, Fusion/analysis/genetics [MESH]
  • |*Receptor, Platelet-Derived Growth Factor alpha/analysis/genetics [MESH]
  • |*mRNA Cleavage and Polyadenylation Factors/analysis/genetics [MESH]
  • |Biopsy/methods [MESH]
  • |Bone Marrow/*pathology [MESH]
  • |Humans [MESH]
  • |Magnetic Resonance Imaging, Cine/methods [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Prednisone/*administration & dosage [MESH]
  • |Stroke Volume [MESH]


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