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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2018 ; 97
(11
): e0079
Nephropedia Template TP
gab.com Text
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English Wikipedia
Loeffler endocarditis as a rare cause of heart failure with preserved ejection
fraction: A case report and review of literature
#MMPMID29538200
Gao M
; Zhang W
; Zhao W
; Qin L
; Pei F
; Zheng Y
Medicine (Baltimore)
2018[Mar]; 97
(11
): e0079
PMID29538200
show ga
RATIONALE: Hypereosinophilic syndrome (HES) is a rare disease characterized by
hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided
into 3 chronological stages: an acute necrotic stage; a thrombus formation stage;
and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells
followed by endomyocardial fibrosis is known as "Loeffler endocarditis." PATIENT
CONCERNS: We report a case of a 60-year-old man diagnosed with left-sided
restrictive cardiomyopathy. DIAGNOSIS: The patient experienced heart failure with
preserved ejection fraction. The cardiac MRI showed intense, linear, delayed
gadolinium enhancement of the endocardium of the lateral wall of the left
ventricle, and obliteration of the LV apex. He was ultimately identified as
Loeffler endocarditis. INTERVENTION: A bone marrow smear and biopsy revealed the
FIP1L1-PDGFRA fusion gene was positive in 82% of segmented nucleated cells.
OUTCOME: Our patient responded well to prednisone at 1?mg/kg/d. LESSONS: HES is a
rare disease that often afflicts the heart. Cardiac involvement in
hypereosinophilia, especially Loeffler endocarditis, carries a poor prognosis and
significant mortality. Early detection and treatment of the disease is therefore
essential. Further studies are needed to ascertain therapeutic corticosteroid
dosages and develop targeted gene therapies, both important steps to ameliorate
the effects of Loeffler endocarditis and improve patient outcomes.