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10.5483/BMBRep.2018.51.3.027 http://scihub22266oqcxt.onion/10.5483/BMBRep.2018.51.3.027 C5882220!5882220!29397870     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2018 ; 51 (3): 134-42 Nephropedia Template TP {{tp|p=29397870|t=2018. Upstream paths for Hippo signaling in Drosophila organ development |pdf=|usr=}}{{29397870}} gab.com Text Upstream paths for Hippo signaling in Drosophila organ development JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=29397870 #FOAvip Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional coactivator Yorkie (Yki). Activation of Yki promotes cell survival and proliferation to induce organ growth. A key issue in Hippo signaling is to understand how core kinase cascade is activated. Activation of Hippo kinase cascade is regulated in the upstream by at least two transmembrane proteins Crumbs and Fat that act in parallel. These membrane proteins interact with additional factors such as FERM-domain proteins Expanded and Merlin to modulate subcellular localization and function of the Hippo kinase cascade. Hippo signaling is also influenced by cytoskeletal networks and cell tension in epithelia of developing organs. These upstream events in the regulation of Hippo signaling are only partially understood. This review focuses on our current understanding of some upstream processes involved in Hippo signaling in developing Drosophila organs. Twit Text FOAVip Upstream paths for Hippo signaling in Drosophila organ development ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=29397870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29397870 #FOAvip English Wikipedia <ref>{{Cite pmid|29397870}}</ref> Upstream paths for Hippo signaling in Drosophila organ development #MMPMID29397870 Choi KW BMB Rep 2018[Mar]; 51 (3): 134-42 PMID29397870show ga Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional coactivator Yorkie (Yki). Activation of Yki promotes cell survival and proliferation to induce organ growth. A key issue in Hippo signaling is to understand how core kinase cascade is activated. Activation of Hippo kinase cascade is regulated in the upstream by at least two transmembrane proteins Crumbs and Fat that act in parallel. These membrane proteins interact with additional factors such as FERM-domain proteins Expanded and Merlin to modulate subcellular localization and function of the Hippo kinase cascade. Hippo signaling is also influenced by cytoskeletal networks and cell tension in epithelia of developing organs. These upstream events in the regulation of Hippo signaling are only partially understood. This review focuses on our current understanding of some upstream processes involved in Hippo signaling in developing Drosophila organs. äUpstream paths for Hippo signaling in Drosophila organ development (epmc).pdf DeepDyve Pubget Overpricing