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10.1002/2211-5463.12400 http://scihub22266oqcxt.onion/10.1002/2211-5463.12400 C5881532!5881532 !29632818     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29632818 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FEBS+Open+Bio 2018 ; 8 (4 ): 664-670 Nephropedia Template TP {{tp|p=29632818 |t=2018. Obesity-associated glomerular inflammation increases albuminuria without renal histological changes |pdf=|usr=}}{{29632818 }} gab.com Text Obesity-associated glomerular inflammation increases albuminuria without renal histological changes JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=29632818 #FOAvip Obesity is one of risk factors for chronic kidney disease (CKD), but the precise mechanism involved is unclear. This study characterizes the effect of obesity-induced glomerular inflammation, oxidative stress, and albuminuria in obese rats. Glomerular samples were collected from fatty (ZF) and lean (ZL) Zucker rats. After 2 months of feeding, body weight and albuminuria were significantly increased in ZF rats when compared to ZL rats. Expression of the inflammatory markers TNF-? and CCR2 was significantly increased in the glomeruli of ZF rats. However, expression of IL-6 mRNA was not increased. Analysis of renal pathology showed no glomerular expansion. As inflammatory and oxidative stress markers are associated with NF-?B, we evaluated whether NF-?B activation was increased in the glomeruli of mice on a high-fat diet. Immunohistochemistry showed increased NF-?B activation in the glomeruli when transgenic mice overexpressing an NF-?B-dependent enhanced green fluorescent protein were fed with a high-fat diet. These results suggest that obesity of only 2 months duration can cause albuminuria, due to increased inflammation or oxidative stress, but may not be long enough to develop renal pathological changes. Twit Text FOAVip Obesity-associated glomerular inflammation increases albuminuria without renal histological changes ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=29632818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632818 #FOAvip English Wikipedia <ref>{{Cite pmid|29632818 }}</ref> Obesity-associated glomerular inflammation increases albuminuria without renal histological changes #MMPMID29632818 Mima A ; Yasuzawa T ; King GL ; Ueshima S FEBS Open Bio 2018[Apr]; 8 (4 ): 664-670 PMID29632818 show ga Obesity is one of risk factors for chronic kidney disease (CKD), but the precise mechanism involved is unclear. This study characterizes the effect of obesity-induced glomerular inflammation, oxidative stress, and albuminuria in obese rats. Glomerular samples were collected from fatty (ZF) and lean (ZL) Zucker rats. After 2 months of feeding, body weight and albuminuria were significantly increased in ZF rats when compared to ZL rats. Expression of the inflammatory markers TNF-? and CCR2 was significantly increased in the glomeruli of ZF rats. However, expression of IL-6 mRNA was not increased. Analysis of renal pathology showed no glomerular expansion. As inflammatory and oxidative stress markers are associated with NF-?B, we evaluated whether NF-?B activation was increased in the glomeruli of mice on a high-fat diet. Immunohistochemistry showed increased NF-?B activation in the glomeruli when transgenic mice overexpressing an NF-?B-dependent enhanced green fluorescent protein were fed with a high-fat diet. These results suggest that obesity of only 2 months duration can cause albuminuria, due to increased inflammation or oxidative stress, but may not be long enough to develop renal pathological changes. äObesity-associated glomerular inflammation increases albuminuria witho(epmc).pdf DeepDyve Pubget Overpricing