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10.1002/ehf2.12251 http://scihub22266oqcxt.onion/10.1002/ehf2.12251 C5880656!5880656 !29345425     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29345425 &cmd=llinks): Failed to open stream: HTTP request failed! 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Eligibility of sacubitril-valsartan in a real-world heart failure population: a community-based single-centre study |pdf=|usr=}}{{29345425 }} gab.com Text Eligibility of sacubitril-valsartan in a real-world heart failure population: a community-based single-centre study JO: ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=29345425 #FOAvip AIMS: This study aims to investigate the eligibility of the Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor (ARNI) with ACE inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study to a real-world heart failure population. METHODS AND RESULTS: Medical records of all heart failure patients living within the catchment area of Umeå University Hospital were reviewed. This district consists of around 150 000 people. Out of 2029 patients with a diagnosis of heart failure, 1924 (95%) had at least one echocardiography performed, and 401 patients had an ejection fraction of ?35% at their latest examination. The major PARADIGM-HF criteria were applied, and 95 patients fulfilled all enrolment criteria and thus were eligible for sacubitril-valsartan. This corresponds to 5% of the overall heart failure population and 24% of the population with ejection fraction ? 35%. The eligible patients were significantly older (73.2 ± 10.3 vs. 63.8 ± 11.5 years), had higher blood pressure (128 ± 17 vs. 122 ± 15 mmHg), had higher heart rate (77 ± 17 vs. 72 ± 12 b.p.m.), and had more atrial fibrillation (51.6% vs. 36.2%) than did the PARADIGM-HF population. CONCLUSIONS: Only 24% of our real-world heart failure and reduced ejection fraction population was eligible for sacubitril-valsartan, and the real-world heart failure and reduced ejection fraction patients were significantly older than the PARADIGM-HF population. The lack of data on a majority of the patients that we see in clinical practice is a real problem, and we are limited to extrapolation of results on a slightly different population. This is difficult to address, but perhaps registry-based randomized clinical trials will help to solve this issue. Twit Text FOAVip Eligibility of sacubitril-valsartan in a real-world heart failure population: a community-based single-centre study ????ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=29345425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29345425 #FOAvip English Wikipedia <ref>{{Cite pmid|29345425 }}</ref> Eligibility of sacubitril-valsartan in a real-world heart failure population: a community-based single-centre study #MMPMID29345425 Norberg H ; Bergdahl E ; Lindmark K ESC Heart Fail 2018[Apr]; 5 (2 ): 337-343 PMID29345425 show ga AIMS: This study aims to investigate the eligibility of the Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor (ARNI) with ACE inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study to a real-world heart failure population. METHODS AND RESULTS: Medical records of all heart failure patients living within the catchment area of Umeå University Hospital were reviewed. This district consists of around 150 000 people. Out of 2029 patients with a diagnosis of heart failure, 1924 (95%) had at least one echocardiography performed, and 401 patients had an ejection fraction of ?35% at their latest examination. The major PARADIGM-HF criteria were applied, and 95 patients fulfilled all enrolment criteria and thus were eligible for sacubitril-valsartan. This corresponds to 5% of the overall heart failure population and 24% of the population with ejection fraction ? 35%. The eligible patients were significantly older (73.2 ± 10.3 vs. 63.8 ± 11.5 years), had higher blood pressure (128 ± 17 vs. 122 ± 15 mmHg), had higher heart rate (77 ± 17 vs. 72 ± 12 b.p.m.), and had more atrial fibrillation (51.6% vs. 36.2%) than did the PARADIGM-HF population. CONCLUSIONS: Only 24% of our real-world heart failure and reduced ejection fraction population was eligible for sacubitril-valsartan, and the real-world heart failure and reduced ejection fraction patients were significantly older than the PARADIGM-HF population. The lack of data on a majority of the patients that we see in clinical practice is a real problem, and we are limited to extrapolation of results on a slightly different population. This is difficult to address, but perhaps registry-based randomized clinical trials will help to solve this issue. |Aged [MESH] |Aminobutyrates/*administration & dosage [MESH] |Angiotensin Receptor Antagonists/administration & dosage [MESH] |Biphenyl Compounds [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Combinations [MESH] |Eligibility Determination/*methods [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Heart Failure/*drug therapy/epidemiology/physiopathology [MESH] |Heart Rate/drug effects/*physiology [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Morbidity/trends [MESH] |Population Surveillance/*methods [MESH] |Retrospective Studies [MESH] |Stroke Volume/drug effects/*physiology [MESH] |Survival Rate/trends [MESH] |Sweden/epidemiology [MESH] |Tetrazoles/*administration & dosage [MESH] |Treatment Outcome [MESH]Eligibility of sacubitril-valsartan in a real-world heart failure popu(epmc).pdf DeepDyve Pubget Overpricing